Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL049219-10
Application #
6490703
Study Section
Special Emphasis Panel (NSS)
Program Officer
Rabadan-Diehl, Cristina
Project Start
1993-01-01
Project End
2005-12-31
Budget Start
2002-01-01
Budget End
2002-12-31
Support Year
10
Fiscal Year
2002
Total Cost
$261,625
Indirect Cost
Name
Medical College of Wisconsin
Department
Physiology
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Mori, Takefumi; Polichnowski, Aaron; Glocka, Padden et al. (2008) High perfusion pressure accelerates renal injury in salt-sensitive hypertension. J Am Soc Nephrol 19:1472-82
Mori, Takefumi; O'Connor, Paul M; Abe, Michiaki et al. (2007) Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk. Hypertension 49:1336-41
O'Connor, Paul M; Cowley Jr, Allen W (2007) Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway. Am J Physiol Renal Physiol 293:F526-32
Abe, Michiaki; O'Connor, Paul; Kaldunski, Mary et al. (2006) Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb. Am J Physiol Renal Physiol 291:F350-7
Morrison, Jolean; Knoll, Kristen; Hessner, Martin J et al. (2004) Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response. Physiol Genomics 17:271-82
Cowley Jr, Allen W; Mori, Takefumi; Mattson, David et al. (2003) Role of renal NO production in the regulation of medullary blood flow. Am J Physiol Regul Integr Comp Physiol 284:R1355-69
Yuan, Baozhi; Liang, Mingyu; Yang, Zhizhang et al. (2003) Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II. Am J Physiol Regul Integr Comp Physiol 284:R1219-30
Mori, Takefumi; Dickhout, Jeffrey G; Cowley Jr, Allen W (2002) Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct. Hypertension 39:465-9
Yuan, B; Cowley Jr, A W (2001) Evidence that reduced renal medullary nitric oxide synthase activity of dahl s rats enables small elevations of arginine vasopressin to produce sustained hypertension. Hypertension 37:524-8
Szentivanyi Jr, M; Park, F; Maeda, C Y et al. (2000) Nitric oxide in the renal medulla protects from vasopressin-induced hypertension. Hypertension 35:740-5

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