The objectives of this study are to (1) provide a greater delay of relapse among schizophrenic patients in the second post discharge year and (2) to enhance the levels of interepisodic adjustment. Based upon an analysis of our recent findings, as well as evidence from the neurosciences and environmental psychology, we propose to develop and test a theoretically based and diagnostic specific PERSONAL TREATMENT of schizophrenia. Unlike contemporary psycho-social treatment studies, we wish to broaden the population base to include patients living in low EE households, patients living alone and a greater number of female patients. In a randomized """"""""pilot"""""""" study, we seek to determine the main and additive effects of Personal Treatment, Family Treatment and Drug (alone and in combination) among 80 patients returning to live with family. In an independent trial, 40 patients living alone will be randomized to Personal Treatment or to a control. We seek to determine the """"""""limits of treatment"""""""" on personal and social adjustment. Further, we wish to explore relationships between patient characteristics, treatment components and outcome as the basis for a future prospective trial wherein patients will be randomized to the hypothesized treatment of choice.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37MH030750-19
Application #
2244256
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-04-01
Project End
1996-09-29
Budget Start
1996-02-15
Budget End
1996-09-29
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Hogarty, Gerard E; Greenwald, Deborah P; Eack, Shaun M (2006) Durability and mechanism of effects of cognitive enhancement therapy. Psychiatr Serv 57:1751-7
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Keshavan, M S; Hogarty, G E (1999) Brain maturational processes and delayed onset in schizophrenia. Dev Psychopathol 11:525-43
Hogarty, G E; Flesher, S (1999) Practice principles of cognitive enhancement therapy for schizophrenia. Schizophr Bull 25:693-708
Hogarty, G E; Flesher, S (1999) Developmental theory for a cognitive enhancement therapy of schizophrenia. Schizophr Bull 25:677-92
Hogarty, G E; Greenwald, D; Ulrich, R F et al. (1997) Three-year trials of personal therapy among schizophrenic patients living with or independent of family, II: Effects on adjustment of patients. Am J Psychiatry 154:1514-24
Hogarty, G E; Kornblith, S J; Greenwald, D et al. (1997) Three-year trials of personal therapy among schizophrenic patients living with or independent of family, I: Description of study and effects on relapse rates. Am J Psychiatry 154:1504-13
Carter, M; Flesher, S (1995) The neurosociology of schizophrenia: vulnerability and functional disability. Psychiatry 58:209-24
Hogarty, G E; Kornblith, S J; Greenwald, D et al. (1995) Personal therapy: a disorder-relevant psychotherapy for schizophrenia. Schizophr Bull 21:379-93
Hogarty, G E; Anderson, C M; Reiss, D J et al. (1991) Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare treatment of schizophrenia. II. Two-year effects of a controlled study on relapse and adjustment. Environmental-Personal Indicators in the Course of Schizophreni Arch Gen Psychiatry 48:340-7

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