Bombesin is a gastrointestinal hormone and neurally active peptide. It stimulates gastric acid secretion via gastrin release. The peptide is behaviorally active in suppressing food intake and lowers body temperature. The mammalian endogenous form of the peptide is ectopically produced in small cell carcinoma of the lung. These tumor cells also have bombesin receptors. Therefore, a possible means of chemotherapy could consist of drugs derived from this peptide. The synthesis of a series of analogues is proposed. One group is composed of agonist peptides designed for enhanced potency and efficacy. The peptides contain a minimum active sequence with changes to stabilize the conformation. Included in this group is a cyclic analogue. In the other group are possible specific antagonists. The peptides will be screened for activity and antagonism in chemotaxis to macrophages and tumor cells and in food intake behavior.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43CA044399-01
Application #
3491714
Study Section
Biophysics and Biophysical Chemistry A Study Section (BBCA)
Project Start
1986-09-15
Project End
1987-03-14
Budget Start
1986-09-15
Budget End
1987-03-14
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Peptide Technologies Corporation
Department
Type
DUNS #
City
Gaithersburg
State
MD
Country
United States
Zip Code
20877