Currently, mammography is an important tool in breast cancer screening and has been shown to reduce mortality by early detection. Despite being a very sensitive technique, mammography's specificity is limited in that only approximately 10-30% of mammographically-directed biopsies are positive. Both PET and single-photon Nuclear Medicine imaging studies using Thallium-201, Technetium-99m Sestamibi, and F-18 Fluorodeoxyglucose have been shown to provide sensitive and specific detection of breast cancers. Nuclear Medicine studies would provide cost-effective methods for Secondary breast cancer screening by limiting the number of negative biopsies. For this Purpose, we propose a dedicated Nuclear Medicine breast imaging device based on NaI(T1) detectors capable of performing both PET and single-photon studies. Since both PET and single-photon radiotracers are likely to play a role in breast cancer detection, a device capable of imaging both tracers is ideally suited to the task. Besides improving the quality of breast imaging over current instrumentation, this device should be sufficiently inexpensive to make Nuclear Medicine breast cancer imaging cost-effective as a secondary Screening method. In this Phase I application, we propose to study the feasibility of this device and begin its overall design.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43CA066514-01
Application #
2109887
Study Section
Special Emphasis Panel (ZRG7-SSS-7 (19))
Project Start
1995-03-10
Project End
1995-09-09
Budget Start
1995-03-10
Budget End
1995-09-09
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Ugm Laboratory, Inc.
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104