Nanoprobes, Inc. has devised metal-enhanced radiation therapy [MERT], a method for cancer therapy that combines targeted delivery of heavy metal (such as gold) with tumor-focused gamma or x-ray irradiation. We now propose to study the application of MERT to solid tumors and to elucidate its mechanisms and limitations. Firstly, additional calculations and modeling will further our theoretical understanding. Secondly, the delivery of gold to human tumors in vitro and in nude mice will be optimized by examining four types of gold particles and three types of targeting molecules. Thirdly, the targeted gold will be irradiated to determine the efficacy.

Proposed Commercial Applications

If successful, Nanoprobes, Inc. will have developed useful targeted gold reagents useful for ancillary cancer therapy and management. These reagents would then have commercial importance.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43CA083576-01A1
Application #
6146792
Study Section
Special Emphasis Panel (ZRG1-RAD (05))
Program Officer
Stone, Helen B
Project Start
2000-06-07
Project End
2001-10-30
Budget Start
2000-06-07
Budget End
2001-10-30
Support Year
1
Fiscal Year
2000
Total Cost
$173,304
Indirect Cost
Name
Nanoprobes, Inc.
Department
Type
DUNS #
784163446
City
Yaphank
State
NY
Country
United States
Zip Code
11980
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