Brachytherapy seed eye plaques are commonly used in the treatment of ocular melanomas and macular degeneration. In addition to being relatively bulky, the dose distribution generated by the seed cores is non-uniform and highly complex. With the non-spherical iso-dose radiation profiles of each seed and variations in individual seed activities, it is an extremely involved and difficult process to accurately calculate the radiation dose rate at varying points within the eye and even within the tumor. A plan is proposed in which a novel uniformly distributed radioactive plaque is fabricated. The plaque shall consist of an 125I ion implanted thin foil attached to a 0.5 mm thick gold protective shield. The gold shield shall also act as a radiation collimator to protect normal structures located at the periphery of the plaque. A spacer will be used to seal the radioactive source. This plaque would provide accurate radiation dosimetry and would be three times thinner than current eye plaques. Tumor irradiation plans using such a plaque would optimize the dose to the tumor while minimizing the dose to normal ocular structures resulting in an significant decrease in radiation induced ocular complications.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43CA092913-01
Application #
6404184
Study Section
Special Emphasis Panel (ZRG1-SSS-R (10))
Program Officer
Stone, Helen B
Project Start
2001-09-01
Project End
2002-06-30
Budget Start
2001-09-01
Budget End
2002-06-30
Support Year
1
Fiscal Year
2001
Total Cost
$105,526
Indirect Cost
Name
Implant Sciences Corporation
Department
Type
DUNS #
City
Wakefield
State
MA
Country
United States
Zip Code
01880