The need for a cancellous bone substitute, in the form of an artificial biocompatible implant, is significant. Research has demonstrated that an implant ideally should serve as a porous framework for bone regeneration. In this program, Ultramet proposes a novel biomedical application of a material originally developed for nonmedical purposes. Reticulated carbon foam will be infiltrated with tantalum by chemical vapor infiltration (CVI), a variation of the chemical vapor deposition (CVD) process. Tantalum has a long history of use as an implant material, in both bone and soft tissue. In Phase I, Ultramet will demonstrate the feasibility of producing tantalum foams in several porosities and configurations, and the CVI process for tantalum will be refined and initially optimized. The materials fabricated by Ultramet will then be evaluated by the Department of Bioengineering, Clemson University, which will conduct extensive mechanical testing and corrosion studies. The results of the mechanical tests performed on reticular tantalum will be compared to accepted values for cancellous bone.This lightweight, strong, porous structure, mimicking the microstructure of natural cancellous bone, will act as a matrix for the incorporation of bone, providing optimal permeability and a high surface area to encourage new bone ingrowth.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43DE009781-01A1
Application #
3495273
Study Section
Special Emphasis Panel (SSS (B8))
Project Start
1992-06-01
Project End
1992-12-31
Budget Start
1992-06-01
Budget End
1992-12-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Ultramet
Department
Type
DUNS #
City
Pacoima
State
CA
Country
United States
Zip Code
91331