Abstract

The prevalence of obesity is rising to epidemic proportions around the world at an alarming rate. Obesity is a serious medical problem: in the United States, it is estimated that about 300,000 deaths are caused by obesity every year; more than $100 billion is spent each year for the treatment of obesity and its primary co-morbidities. However, currently there is no satisfactory therapy for morbid obesity and there is a great need to explore new therapeutic options. The long-term aim of this project is to develop a safe and effective therapy using intestinal electrical stimulation for the treatment of morbid obesity. This is based on our preliminary data demonstrating that intestinal electrical stimulation inhibits gastric motility, induces vomiting and reduces food intake.
The aim of this project is to prove feasibility of intestinal electrical stimulation for the treatment of obesity in dogs.
Specific aims are: 1) to study the effect of intestinal electrical stimulation on gastric tone/contractions as well as gastric emptying and to derive the most effective stimulation method that inhibits gastric motility; 2) to investigate the efficacy and safety of intestinal electrical stimulation in reducing food intake; and 3) to study vagally-mediated mechanisms involved with intestinal electrical stimulation. It is anticipated that intestinal electrical stimulation inhibits gastric contractions or induces gastric relaxation, impairs gastric myoelectrical activity and delays gastric emptying, leading to a significant reduction in food intake in a canine model. It is further hypothesized that the inhibitory effects of intestinal electrical stimulation on gastric motility and food intake are mediated via the vagal afferent pathway. Further studies on the long-term effects of intestinal electrical stimulation on weight loss, possible mechanisms involving certain hormones, such as CCK, and the development of an implantable stimulator will be the topics of the Phase II application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43DK063733-01
Application #
6583797
Study Section
Special Emphasis Panel (ZRG1-SSS-3 (10))
Program Officer
Kuczmarski, Robert J
Project Start
2003-03-15
Project End
2003-09-30
Budget Start
2003-03-15
Budget End
2003-09-30
Support Year
1
Fiscal Year
2003
Total Cost
$100,000
Indirect Cost

  Institution

Name
Transneuronix, Inc.
Department
Type
DUNS #
City
MT. Arlington
State
NJ
Country
United States
Zip Code
07856

  Publications

Zhao, Xiaotuan; Yin, Jieyun; Wang, Lijie et al. (2014) Diffused and sustained inhibitory effects of intestinal electrical stimulation on intestinal motility mediated via sympathetic pathway. Neuromodulation 17:373-79; discussion 380
Xu, Xiaohong; Lei, Yong; Chen, Jiande D Z (2011) Duodenum electrical stimulation delays gastric emptying, reduces food intake and accelerates small bowel transit in pigs. Obesity (Silver Spring) 19:442-8
Xu, Xiaohong; Lei, Yong; Chen, Jiande D Z (2010) Effects and mechanisms of electrical stimulation of the stomach, duodenum, ileum, and colon on gastric tone in dogs. Dig Dis Sci 55:895-901
Yin, Jieyun; Chen, Jiande D Z (2010) Mechanisms and potential applications of intestinal electrical stimulation. Dig Dis Sci 55:1208-20
Sun, Y; Chen, J D Z (2009) Intestinal electric stimulation accelerates whole gut transit and promotes fat excrement in conscious rats. Int J Obes (Lond) 33:817-23
Zhang, Jing; Zhu, Hongbing; Chen, J D Z (2009) Central neuronal mechanisms of intestinal electrical stimulation: effects on duodenum distention-responsive (DD-R) neurons in the VMH of rats. Neurosci Lett 457:27-31
Zhang, Jing; Tang, Ming; Chen, Jiande D Z (2009) Gastric electrical stimulation for obesity: the need for a new device using wider pulses. Obesity (Silver Spring) 17:474-80
Zhao, Xiaotuan; Yin, Jieyun; Chen, Jihong et al. (2009) Inhibitory effects and mechanisms of intestinal electrical stimulation on gastric tone, antral contractions, pyloric tone, and gastric emptying in dogs. Am J Physiol Regul Integr Comp Physiol 296:R36-42
Song, Geng-Qing; Hou, Xiaohua; Yang, Bin et al. (2008) A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs. Surgery 143:72-8
Yin, Jieyun; Ouyang, Hui; Chen, Jiande D Z (2007) Potential of intestinal electrical stimulation for obesity: a preliminary canine study. Obesity (Silver Spring) 15:1133-8

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