Objective measurement of retinal function is essential in assisting in the diagnosis and evaluation of treatment results of several diseases afflicting the eye, such as glaucoma, hypertensive retinopathy, diabetic retinopathy, macular diseases such as central serous retinopathy, and toxic neuropathy, etc. The long term objective of the project proposed in this application is to develop a clinically useful confocal scanning laser ellipsometer to objectively assess in vivo retinal function by measuring the transient birefringence change in the retinal nerve fiber layer (RNFL) related to ganglion cell activity. During Phase I, we will design and build a prototype system, develop software for data processing and display, pursue the measurement of birefringence change related to ganglion cell activity in the RNFL, evaluate the sensitivity and reproducibility of the prototype system, and perform preliminary clinical studies.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43EY012054-01
Application #
2536657
Study Section
Special Emphasis Panel (ZRG1-VISB (07))
Project Start
1998-02-01
Project End
1998-07-31
Budget Start
1998-02-01
Budget End
1998-07-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Laser Diagnostic Technologies, Inc.
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92127