The development of an Atmospheric Scanning Proton Microprobe (ASPM) for elemental analysis of organic specimens is proposed. The instrument will be capable of mapping elemental distributions in concentrations as low as 1 ppm. The ability to bring high energy protons into air will allow the analysis of hydrated organic specimens with little or no special preparation, avoiding distortion of the elemental distributions. The ASPM uses Proton Induced X- Ray Emission (PIXE), a general analysis technique for bulk specimens. The use of a collimated proton beam, scanning stage and vacuum window will provide the capability to analyze the specimen in air with moderate spatial resolution (>10 microns). Phase I research will be used to instrument an existing test beamline. A Personal Computer based acquisition and control system will be developed for area mapping and display. The resulting system will be used to evaluate the use of low energy (.5-2 Mev) proton beams for the analysis of organic specimens, with the goal of identifying a minimum energy accelerator suitable for development into a self-contained analytical tool. Phase II will be used to produce the prototype of a dedicated system including accelerator, beamline, and control system.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43GM047206-01
Application #
3498756
Study Section
Special Emphasis Panel (SSS (B6))
Project Start
1992-01-15
Project End
1992-07-14
Budget Start
1992-01-15
Budget End
1992-07-14
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Pyramid Technical Consultants, Inc.
Department
Type
DUNS #
City
Lexington
State
MA
Country
United States
Zip Code
02421