The overall objective of this research is to develop a new laboratory instrument capable of both synthesizing and analyzing combinatorial arrays in a """"""""tape cassette"""""""" format. The proposed format allows large arrays to be conveniently synthesized and analyzed within a compact volume, The tape format offers significant handling advantages over the two dimensional """"""""chip"""""""" format currently under investigation by a variety of researchers. Phase I research will involve developing an appropriate chemistry for the tape/matrix/array system, synthesizing a model combinatorial array on a tape, and validating the synthesis method by chemical analysis of array members, and by antibody recognition of an array member. Successful completion of Phase I research would demonstrate that combinatorial arrays can be synthesized in a tape format. Phase II research would then focus on developing a prototype instrument that automatically synthesizes arrays designed by the user.

Proposed Commercial Applications

Successful completion of the proposed research would lead to a new instrument for synthesizing and analyzing combinatorial arrays.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43GM060069-01
Application #
6014926
Study Section
Special Emphasis Panel (ZRG1-SSS-2 (01))
Project Start
1999-09-01
Project End
2000-02-29
Budget Start
1999-09-01
Budget End
2000-02-29
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
H and N Instruments, Inc.
Department
Type
DUNS #
City
Newark
State
OH
Country
United States
Zip Code
43055