This application proposes a computer based information service to provide decision support to physicians and patients in treatment selection in Mitral Valve disease. Studies indicate significant differences in morbidity and mortality rates between Mitral Valve Reconstruction and Mitral Value Replacement. Thus, large numbers of complex clinical and nonclinical factors affect and are affected by the treatment selected. The technology proposed uses a methodology for systematically assessing these factors against the potential consequences associated with each possible treatment. The methodology is to be transformed into a computer program capable of analyzing a large variety of data. The program will analyze the impact on the patient of early surgery of Mitral Valve Reconstruction versus deferred surgery for Mitral Valve Replacement. This technology, with appropriate modification, can be used for other medical conditions for which there is a choice of treatments. By giving physicians and their patients easy access to these programs, through a computer-based information service, large numbers of patients may be served regardless of their location. In the instance of Mitral Valve disease, the potential user group is the pre-operational population of approximately 400,000 per year. With advanced knowledge about the impact of treatments on each patient, a better match of patients with treatment can occur resulting in the more effective use of health care resources.

Project Start
1988-04-07
Project End
1988-10-06
Budget Start
1988-04-07
Budget End
1988-10-06
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Computerized Health Evaluation Sys, Inc.
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90024
Li, Ming V; Chen, Weiqin; Harmancey, Romain N et al. (2010) Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun 395:395-400