The overall high rate of successful cardiac catheterizations for diagnosis or angioplasty has been offset by the significant number of failures in these often crucial procedures. A common difficulty stems from the inability to precisely direct movements of the percutaneously introduced catheter tip by manual manipulation. Venous catheters must be manipulated through the pulmonary valve while arterial catheters and wires must be threaded around a sharp bend into the chosen branch of the coronary vessel and past an atheromatous obstruction. It is proposed to use the forces resulting from placement of magnetic or magnetizable materials in a spatially varying, externally controlled magnetic field to aid in positioning the catheter tip. The susceptible volume of the catheter, magnetized by the external control field, experiences a force due to the magnetic flux density gradient. With a suitable field configuration, an effective controller, and the use of the fluoroscopically obtained visual feedback normally utilized in the standard catheterization technique, the physician can apply precisely directed increments of force. In Phase I, various magnetic configurations and control approaches will be evaluated both in simulations and in a scaled, laboratory pre-prototype. The result will be a design for a practical magnetic guiding system which is compatible with existing catheterization laboratory equipment and techniques. In Phase II, a laboratory prototype will be fabricated and tested.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL046061-01
Application #
2222661
Study Section
Special Emphasis Panel (SSS (B1))
Project Start
1991-09-30
Project End
1992-03-31
Budget Start
1991-09-30
Budget End
1992-03-31
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Satcon Technology Corporation
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Calfee, Carolyn S; Thompson, B Taylor; Parsons, Polly E et al. (2010) Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med 38:1436-41
Parikh, Chirag R; Abraham, Edward; Ancukiewicz, Marek et al. (2005) Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol 16:3046-52