The objective of this project is to develop a grid-free CFD software for the simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) """"""""systems"""""""" as they respond to physiologically realistic 3-D pulsatile flow, which includes laminar and turbulent flow regimes as well as transition between the two regimes. The final product will be the first commercially available grid-free """"""""virtual MPHV test chamber"""""""", which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable.
The research aims specifically at (1) coupling an existing MPI-parallel, fast Lagrangian vortex element method with a structural dynamics code, and (2) validating the resultant software using physiologically realistic test cases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL078045-01
Application #
6832970
Study Section
Special Emphasis Panel (ZRG1-SSS-W (10))
Program Officer
Baldwin, Tim
Project Start
2004-08-01
Project End
2005-03-31
Budget Start
2004-08-01
Budget End
2005-03-31
Support Year
1
Fiscal Year
2004
Total Cost
$100,000
Indirect Cost
Name
Applied Scientific Research
Department
Type
DUNS #
046276809
City
Santa Ana
State
CA
Country
United States
Zip Code
92612