The diagnosis of certain congenital heart defects can now be made as early as 12 weeks of gestation due to advances in fetal echocardiography. Fetal cardiac surgery, which has been investigated since the early 1980s, is an increasingly viable solution to prevent simple cardiac lesions from progressing into serious defects requiring major surgery. The most significant obstacle to successful fetal cardiac bypass has been placental dysfunction, causes of which include blood contact with extracorporeal surfaces, priming substances (maternal blood), and increased placental vascular resistance. The goal of this proposal is to develop a novel fetal cardiac bypass circuit capable of delivering pulsatile flow and adequate gas exchange with minimal priming volume. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL079737-01
Application #
6884182
Study Section
Special Emphasis Panel (ZRG1-EMNR-E (10))
Program Officer
Hoke, Tracey R
Project Start
2005-01-01
Project End
2006-06-30
Budget Start
2005-01-01
Budget End
2006-06-30
Support Year
1
Fiscal Year
2005
Total Cost
$95,820
Indirect Cost
Name
Ension, Inc.
Department
Type
DUNS #
100758015
City
Pittsburgh
State
PA
Country
United States
Zip Code
15238