Oscillatory rhythms in the brain are of interest to both physiologists and biopsychologists because they may be part of a mechanism of """"""""sensory- binding' which is hypothesized to synchronize neuronal activity related to a perceptual object. One of the brain waves studied occurs when auditory stimuli are presented at regular intervals at a repetition-rate near 40- Hz. We can now show that these """"""""steady-state"""""""" potentials are generated by summation of a series of transient evoked-responses synchronized to the stimuli. The transient waveforms are different at different repetition- rates. They also show differences depending upon whether or not the stimulus is perceived as having """"""""temporal continuity"""""""", which in Gestalt psychology is referred to as """"""""sequential integration"""""""". These new evoked-responses provide a possible tool for bridging between physiological experiments in animals and biopsychological experiments in humans, concerning brain mechanisms related to sensory or cognitive processes.
This research provides the foundation for commercialization of a PC-based system which can record transient evoked-responses to """"""""steady-state"""""""" stimuli. The demand for the system will come from research laboratories and clinical facilities which record cortical evoked-responses, in either humans or animals.
| Jewett, Don L; Hart, Toryalai; Larson-Prior, Linda J et al. (2006) Human sensory-evoked responses differ coincident with either ""fusion-memory"" or ""flash-memory"", as shown by stimulus repetition-rate effects. BMC Neurosci 7:18 |
| Jewett, Don L (2005) What's wrong with single hypotheses?: Why it is time for Strong-Inference-PLUS. Scientist 19:10 |
| Jewett, Don L; Caplovitz, Gideon; Baird, Bill et al. (2004) The use of QSD (q-sequence deconvolution) to recover superposed, transient evoked-responses. Clin Neurophysiol 115:2754-75 |
