This is a Phase one proposal which responds to the SBIR need for the development of novel methods of monitoring autonomic nervous function, from established investigators at Univ. Ill, Chicago. In this phase 1 project, methods will be developed for a system for instantaneous autonomic function based upon time-frequency analysis of heart rate. A specific time-frequency algorithm will be developed to adapt the characteristics of the HRV time series data to derive 3 characteristic frequency dependent indices for HRV every 30 seconds, including a sympathetic index (SI) a parasympathetic index (PI) and a ratio index (SI/PI). The algorithm will be developed and rigorously validated in dogs (Phase 1) by manipulating sympathetic and parasympathetic nervous input in a novel animal preparation. In Phase 2, they intend to test the algorithm in humans, and develop a compact portable system.

Proposed Commercial Applications

NOT AVAILABLE

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43NS037981-01
Application #
2714706
Study Section
Special Emphasis Panel (ZRG1-NEUA (01))
Program Officer
Kitt, Cheryl A
Project Start
1998-09-01
Project End
1999-04-30
Budget Start
1998-09-01
Budget End
1999-04-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Biotechplex Corporation
Department
Type
DUNS #
City
San Marcos
State
CA
Country
United States
Zip Code
92078