Abstract

There is a need for a non-invasive and continuous bedside monitor for brain oxygenation for adult human patients. Near-infrared spectroscopy (NIRS) is an optically based technique that could meet such demand. However, NIRS instruments have yet to achieve their initially expected potential of becoming routine clinical monitors complementary to pulse oximetry. One major challenge is to develop an optical transducer probe and a corresponding algorithm to solve the problem of interference from extracerebral tissue (skin, scalp, and skull) in adult NIRS applications. Another major challenge is to develop an algorithm that will be able to absolutely quantify the optical signals to derive quantitative variables or indices that are of clinical significance. Our goal is to resolve these challenges to develop an NIRS monitor that will determine absolute brain hemoglobin oxygen saturation on adult patients. The primary objectives of this SBIR proposal are: 1) Design and construct an NIRS monitor for use on adult human patients; 2) Determine the optimum adult NIRS probe configuration to minimize extracerebral interference 3) Evaluate and validate novel adult NIRS algorithms that further minimize extracerebral interference and determine absolute brain oxygen saturation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43NS045488-01
Application #
6585412
Study Section
Special Emphasis Panel (ZRG1-BDCN-2 (11))
Program Officer
Pancrazio, Joseph J
Project Start
2003-02-01
Project End
2003-07-31
Budget Start
2003-02-01
Budget End
2003-07-31
Support Year
1
Fiscal Year
2003
Total Cost
$100,000
Indirect Cost

  Institution

Name
Cas Medical Systems, Inc.
Department
Type
DUNS #
122211543
City
Branford
State
CT
Country
United States
Zip Code
06405

  Publications

Benni, Paul B; MacLeod, David; Ikeda, Keita et al. (2018) A validation method for near-infrared spectroscopy based tissue oximeters for cerebral and somatic tissue oxygen saturation measurements. J Clin Monit Comput 32:269-284
Ikeda, Keita; MacLeod, David B; Grocott, Hilary P et al. (2014) The accuracy of a near-infrared spectroscopy cerebral oximetry device and its potential value for estimating jugular venous oxygen saturation. Anesth Analg 119:1381-92
Fischer, Gregory W; Lin, Hung-Mo; Krol, Marina et al. (2011) Noninvasive cerebral oxygenation may predict outcome in patients undergoing aortic arch surgery. J Thorac Cardiovasc Surg 141:815-21
Fischer, G W; Benni, P B; Lin, H-M et al. (2010) Mathematical model for describing cerebral oxygen desaturation in patients undergoing deep hypothermic circulatory arrest. Br J Anaesth 104:59-66