? Synchrotron radiation is an important tool for structural biological studies using X-ray diffraction, X-ray scattering, and X-ray absorption spectroscopy. The quality of data often depends critically on beam spectral quality. The technical limitations (e.g. energy range) of beamlines can make or break experiments. ? ? In this application we propose to optimize, design, construct, and test over a wide range of energies a novel, inexpensive, easy to align device (""""""""beam cleaner""""""""). The device has several benefits: improving X-ray beam spectral quality; extending (e.g. tripling) the useful energy range of existing beamlines at third generation synchrotron radiation sources by selecting specific harmonics for experimental use; passively compensating for vertical beam motion as the monochromator angle is changed; and focussing the beam. Beam cleaners offer the potential to simplify new beamline designs by permitting use of channel-cut monochromators in vacuum, followed by a beam cleaner arranged so as to passively compensate for vertical beam motion, without the need for precise in-vacuum mechanics. This device also potentially can be used as a non-beam-hardening variable attenuator for experiments on radiation sensitive biological samples at intense third generation sources, and the devices also appear to be applicable to laboratory research. ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43RR018635-01
Application #
6642477
Study Section
Special Emphasis Panel (ZRG1-SSS-7 (10))
Program Officer
Swain, Amy L
Project Start
2003-05-05
Project End
2004-12-01
Budget Start
2003-05-05
Budget End
2004-12-01
Support Year
1
Fiscal Year
2003
Total Cost
$125,000
Indirect Cost
Name
Quercus Technologies
Department
Type
DUNS #
City
Oak Park
State
IL
Country
United States
Zip Code
60304