Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
James A. Shannon Director's Award (R55)
Project #
1R55AR041880-01A1
Application #
3509535
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1993-09-01
Project End
1994-03-14
Budget Start
1993-09-01
Budget End
1994-03-14
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Doudican, Nicole A; Wen, Shih Ya; Mazumder, Amitabha et al. (2014) Identification of agents that promote endoplasmic reticulum stress using an assay that monitors luciferase secretion. J Biomol Screen 19:575-84
Cheng, Tsing; Orlow, Seth J; Manga, Prashiela (2013) Loss of Oca2 disrupts the unfolded protein response and increases resistance to endoplasmic reticulum stress in melanocytes. Pigment Cell Melanoma Res 26:826-34
Wang, Claire Q F; Akalu, Yemsratch T; Suarez-Farinas, Mayte et al. (2013) IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis. J Invest Dermatol 133:2741-2752
Toosi, Siavash; Orlow, Seth J; Manga, Prashiela (2012) Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. J Invest Dermatol 132:2601-9
Manga, Prashiela; Orlow, Seth J (2011) Informed reasoning: repositioning of nitisinone to treat oculocutaneous albinism. J Clin Invest 121:3828-31
Manga, Prashiela; Bis, Sabina; Knoll, Kristen et al. (2010) The unfolded protein response in melanocytes: activation in response to chemical stressors of the endoplasmic reticulum and tyrosinase misfolding. Pigment Cell Melanoma Res 23:627-34
Doudican, Nicole A; Bowling, Benjamin; Orlow, Seth J (2010) Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism. Leuk Res 34:229-34