Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
James A. Shannon Director's Award (R55)
Project #
1R55AR042047-01A2
Application #
2081247
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1994-09-15
Project End
1995-06-14
Budget Start
1994-09-15
Budget End
1995-06-14
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

van Steensel, Maurice A M; Coulombe, Pierre A; Kaspar, Roger L et al. (2014) Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting. J Invest Dermatol 134:588-591
Alvarado, David M; Coulombe, Pierre A (2014) Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice. J Biol Chem 289:19435-47
Chung, Byung-Min; Rotty, Jeremy D; Coulombe, Pierre A (2013) Networking galore: intermediate filaments and cell migration. Curr Opin Cell Biol 25:600-12
Pan, Xiaoou; Hobbs, Ryan P; Coulombe, Pierre A (2013) The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol 25:47-56
Feng, Xia; Zhang, Hao; Margolick, Joseph B et al. (2013) Keratin intracellular concentration revisited: implications for keratin function in surface epithelia. J Invest Dermatol 133:850-853
Kim, Jin Seob; Lee, Chang-Hun; Su, Baogen Y et al. (2012) Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading. Biophys J 103:1828-38
Coulombe, Pierre A; Lee, Chang-Hun (2012) Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. J Invest Dermatol 132:763-75
Lee, Chang-Hun; Kim, Min-Sung; Chung, Byung Min et al. (2012) Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nat Struct Mol Biol 19:707-15
Kim, Jin Seob; Lee, Chang-Hun; Coulombe, Pierre A (2010) Modeling the self-organization property of keratin intermediate filaments. Biophys J 99:2748-56
Lee, Chang-Hun; Coulombe, Pierre A (2009) Self-organization of keratin intermediate filaments into cross-linked networks. J Cell Biol 186:409-21

Showing the most recent 10 out of 13 publications