Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
James A. Shannon Director's Award (R55)
Project #
2R55DK038712-04A1
Application #
3509684
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1987-07-01
Project End
1992-07-14
Budget Start
1991-09-30
Budget End
1992-07-14
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Copps, Kyle D; Hançer, Nancy J; Qiu, Wei et al. (2016) Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. J Biol Chem 291:8602-17
Hançer, Nancy J; Qiu, Wei; Cherella, Christine et al. (2014) Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem 289:12467-84
Rhodes, Christopher J; White, Morris F; Leahy, John L et al. (2013) Direct autocrine action of insulin on ?-cells: does it make physiological sense? Diabetes 62:2157-63
Qi, Yajuan; Xu, Zihui; Zhu, Qinglei et al. (2013) Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38? MAPK during insulin resistance. Diabetes 62:3887-900
Sadagurski, Marianna; Leshan, Rebecca L; Patterson, Christa et al. (2012) IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab 15:703-12
Long, Yun Chau; Cheng, Zhiyong; Copps, Kyle D et al. (2011) Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol 31:430-41
Cheng, Zhiyong; White, Morris F (2011) Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal 14:649-61
Sadagurski, Marianna; Cheng, Zhiyong; Rozzo, Aldo et al. (2011) IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J Clin Invest 121:4070-81
Cheng, Zhiyong; Tseng, Yolanda; White, Morris F (2010) Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab 21:589-98
Cheng, Zhiyong; White, Morris F (2010) Foxo1 in hepatic lipid metabolism. Cell Cycle 9:219-20

Showing the most recent 10 out of 13 publications