This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
James A. Shannon Director's Award (R55)
Project #
1R55DK043805-01A2
Application #
3509696
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1992-09-30
Project End
1994-09-29
Budget Start
1992-09-30
Budget End
1994-09-29
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Carrithers, S L; Barber, M T; Biswas, S et al. (1996) Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues. Proc Natl Acad Sci U S A 93:14827-32
Carrithers, S L; Parkinson, S J; Goldstein, S D et al. (1996) Escherichia coli heat-stable enterotoxin receptors. A novel marker for colorectal tumors. Dis Colon Rectum 39:171-81
Deshmane, S P; Carrithers, S L; Parkinson, S J et al. (1995) Rat guanylyl cyclase C expressed in COS-7 cells exhibits multiple affinities for Escherichia coli heat-stable enterotoxin. Biochemistry 34:9095-102
Urbanski, R; Carrithers, S L; Waldman, S A (1995) Internalization of E. coli ST mediated by guanylyl cyclase C in T84 human colon carcinoma cells. Biochim Biophys Acta 1245:29-36
Carrithers, S L; Parkinson, S J; Goldstein, S et al. (1994) Escherichia coli heat-stable toxin receptors in human colonic tumors. Gastroenterology 107:1653-61
Parkinson, S J; Carrithers, S L; Waldman, S A (1994) Opposing adenine nucleotide-dependent pathways regulate guanylyl cyclase C in rat intestine. J Biol Chem 269:22683-90