Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
James A. Shannon Director's Award (R55)
Project #
1R55HD031191-01A1
Application #
2203585
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1994-09-30
Project End
1995-06-30
Budget Start
1994-09-30
Budget End
1995-06-30
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Salian-Mehta, Smita; Xu, Mei; McKinsey, Timothy A et al. (2015) Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. J Biol Chem 290:14045-56
Salian-Mehta, Smita; Xu, Mei; Pierce, Angela et al. (2014) Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice. Mol Cell Endocrinol 393:164-70
Salian-Mehta, S; Xu, M; Knox, A J et al. (2014) Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism. J Clin Endocrinol Metab 99:1452-60
Salian-Mehta, Smita; Xu, Mei; Wierman, Margaret E (2013) AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival. Mol Cell Endocrinol 374:92-100
Pierce, Angela; Xu, Mei; Bliesner, Brian et al. (2011) Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice. Mol Cell Endocrinol 339:151-8
Wierman, Margaret E; Kiseljak-Vassiliades, Katja; Tobet, Stuart (2011) Gonadotropin-releasing hormone (GnRH) neuron migration: initiation, maintenance and cessation as critical steps to ensure normal reproductive function. Front Neuroendocrinol 32:43-52