Behavioral strategies to cope with potentially threatening or aversive stimuli tend to cluster into two forms: active, escape-driven behaviors, or passive responses that may conserve energy or prevent detection by a predator. Since an individual's coping strategy is closely linked to long-term clinical outcomes after trauma exposure, a better understanding of the neurobiological basis of coping response could greatly impact public health for both men and women. One promising but under-studied area is the role of the endocannabinoid (eCB) system in modulating active vs. passive stress responses. In this project, we will define the contribution of eCB signaling in the medial prefrontal cortex (mPFC) to the mechanisms that underlie coping responses in both sexes. In particular, we will investigate the ability of eCB system to modulate two mPFC-brainstem pathways: mPFC-dorsal raphe (DR) and mPFC-periaqueductal gray (PAG). We will use a combination of behavioral, neuroanatomical, biochemical, and chemogenetic strategies to dissect these circuits. The results of this work will lead to a better understanding of sex-specific stress processes, and have the potential to identify novel therapeutic targets for stress-related mental illnesses.

Public Health Relevance

The way an individual responds to a stressful event can influence that person's risk for subsequent mental illness. This project seeks to understand the neural and biochemical processes that underlie active versus passive stress responses, which could lead to the identification of novel therapeutic targets.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
High Priority, Short Term Project Award (R56)
Project #
1R56MH114193-01
Application #
9545513
Study Section
Neurobiology of Motivated Behavior Study Section (NMB)
Program Officer
Winsky, Lois M
Project Start
2017-09-15
Project End
2019-08-31
Budget Start
2017-09-15
Budget End
2019-08-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Northeastern University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115