This proposal addresses RFA Theme 4 (Focus on Global Health), and RFA Theme 5 (Reinvigorating the Biomedical Research Community). Although many scientific advances in global health have occurred with support from NIH and charitable foundations, often these have stalled in implementation or scalability for the developing world due to lack of affordability, design modeling or business implementation. We are proposing a unique infrastructure at Stanford to accelerate scientific progress in the innovative design of extremely affordable diagnostics, drugs and devices for global health. We will integrate existing multidisciplinary programs in business, design, medicine and engineering at Stanford into a Global Health Consortium focused on Innovation, Design, Evaluation and Action (C-IDEA) (RFA Theme 5). Target areas will include neglected infectious diseases and chronic non-communicable diseases of the developing world (RFA Theme 4). C-IDEA will also utilize economists and social scientists to ensure that the focus on innovative design of new diagnostics, drugs and devices are scalable, have high impact and are able to be implemented and commercialized.
The goal of this project is to focus Stanford University's ground-breaking innovation and design upon the challenges of global public health and the neglected diseases of the developing world. Stanford's multidisciplinary approach to design will be further refined for global health needs and an integrated Global Health Innovation Process will be posted on a public domain website for other institutions to use as a model. Stanford Global Health Consortium (C-IDEA) will strive to advance affordable drugs, devices and diagnostics for low resource settings and medically underserved populations.
|Qvit, Nir; Kornfeld, Opher S (2016) Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation. J Vis Exp :e53589|
|Qvit, Nir; Schechtman, Deborah; Pena, Darlene Aparecida et al. (2016) Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors. Int J Parasitol Drugs Drug Resist 6:74-84|
|Waggoner, Jesse J; Sahadeo, Nikita S D; Brown, Arianne et al. (2015) Improved serotype-specific dengue virus detection in Trinidad and Tobago using a multiplex, real-time RT-PCR. Diagn Microbiol Infect Dis 81:105-6|
|Waggoner, Jesse J; Abeynayake, Janaki; Balassiano, Ilana et al. (2014) Multiplex nucleic acid amplification test for diagnosis of dengue fever, malaria, and leptospirosis. J Clin Microbiol 52:2011-8|
|Waggoner, Jesse J; Abeynayake, Janaki; Sahoo, Malaya K et al. (2013) Comparison of the FDA-approved CDC DENV-1-4 real-time reverse transcription-PCR with a laboratory-developed assay for dengue virus detection and serotyping. J Clin Microbiol 51:3418-20|
|Ren, Kangning; Banaei, Niaz; Zare, Richard N (2013) Sorting inactivated cells using cell-imprinted polymer thin films. ACS Nano 7:6031-6|
|Waggoner, Jesse J; Abeynayake, Janaki; Sahoo, Malaya K et al. (2013) Development of an internally controlled real-time reverse transcriptase PCR assay for pan-dengue virus detection and comparison of four molecular dengue virus detection assays. J Clin Microbiol 51:2172-81|
|Thurber, Mark C; Warner, Christina; Platt, Lauren et al. (2013) To promote adoption of household health technologies, think beyond health. Am J Public Health 103:1736-40|
|Brinton, Todd J; Kurihara, Christine Q; Camarillo, David B et al. (2013) Outcomes from a postgraduate biomedical technology innovation training program: the first 12 years of Stanford Biodesign. Ann Biomed Eng 41:1803-10|
|Fu, Chi-Ling; Odegaard, Justin I; Herbert, De'Broski R et al. (2012) A novel mouse model of Schistosoma haematobium egg-induced immunopathology. PLoS Pathog 8:e1002605|