The objective of this proposal is to acquire a three dimensional micro-computed tomography scanner. This system has the capability of digitizing the three dimensional architecture of biologic specimens at a resolution of between 20 and 40 microns. This system will provide necessary data for multiple investigators studying: the relationship between trabecular bone remodeling and applied stress, the relationship between bone architecture and its mechanical properties; the effects of mechanical, hormonal and drug therapies on the severity and incidence of osteoporosis; the patterns of calcification in atherosclerosis; and the interaction between degradation of articular cartilage and morphologic change subchondral trabecular bone in degenerative joint disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Unknown (S03)
Project #
2S03RR003348-10
Application #
3511983
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-03-01
Project End
1993-02-28
Budget Start
1992-03-06
Budget End
1993-02-28
Support Year
10
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Green, M H; Vermeulen, C W (1994) Fever and the control of gram-negative bacteria. Res Microbiol 145:269-72