Abstract

This application is a second supplement to the SCORE Program which requests support for four projects to further expand the Program's research base. The parent grant was initially funded to support six (6) projects, and the first supplement received funding for an additional five (5) projects starting August 1, 2003. This application is a continuum of the SCORE Program's goal ot developing a new cadre of junior faculty in the biomedical sciences. To that end the application includes only new investigators to the program. Two of the projects are revised versions of prior submissions in the first supplement, and the other two are new projects. Again, the interdisciplinary focus on the neurosciences is carried forth in two projects, and one project focuses on developing an NMR technique capable of detecting airborne toxic chemical and biological agents. The other new project is a novel approach to understanding the mechanism(s) underlying the responsiveness to anti-malarials in people with sickle-cell disease. The disciplines represented are chemistry and physiology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
3S06GM008016-36S1
Application #
7351962
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Toliver, Adolphus
Project Start
1997-08-01
Project End
2010-07-31
Budget Start
2006-09-25
Budget End
2007-07-31
Support Year
36
Fiscal Year
2007
Total Cost
$83,160
Indirect Cost

  Institution

Name
Howard University
Department
Type
Other Domestic Higher Education
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059

  Publications

Faruque, Mezbah U; Chen, Guanjie; Doumatey, Ayo P et al. (2017) Transferability of genome-wide associated loci for asthma in African Americans. J Asthma 54:1-8
Johnston, Henry Richard; Hu, Yi-Juan; Gao, Jingjing et al. (2017) Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome. Sci Rep 7:46398
Kessler, Michael D; Yerges-Armstrong, Laura; Taub, Margaret A et al. (2016) Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry. Nat Commun 7:12521
Liu, Ching-Ti; Raghavan, Sridharan; Maruthur, Nisa et al. (2016) Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet 99:56-75
Rand, Kristin A; Rohland, Nadin; Tandon, Arti et al. (2016) Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk. Hum Mol Genet 25:371-81
Mathias, Rasika Ann; Taub, Margaret A; Gignoux, Christopher R et al. (2016) A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Commun 7:12522
Ehret, Georg B (see original citation for additional authors) (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48:1171-1184
Kurian, P; Dunston, G; Lindesay, J (2016) How quantum entanglement in DNA synchronizes double-strand breakage by type II restriction endonucleases. J Theor Biol 391:102-12
Ogunjirin, Adebowale E; Fortunak, Joseph M; Brown, LaVerne L et al. (2015) Competition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen. Neurochem Res 40:2131-42
Winchester, Danyelle; Ricks-Santi, Luisel; Mason, Tshela et al. (2015) SPINK1 Promoter Variants Are Associated with Prostate Cancer Predisposing Alterations in Benign Prostatic Hyperplasia Patients. Anticancer Res 35:3811-9

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