The long-range goal of the SCORE Program at Meharry Medical College is to assist in improving the competitive status of the school's research enterprise relative to other health science centers in the United States. The program seeks to create a research environment wherein faculty will improve their research skills and capabilities to efficiently conduct high quality research, to disseminate their research through peer-reviewed publications and presentations at national meetings, and to compete with greater success for independent extramural research funds. Finally, research projects ongoing and proposed in this SCORE application will assist the institution in its mission to conduct basic, clinical and applied research with special emphasis on diseases and conditions that disproportionately affect ethnic minority populations. ? ? The revised specific aims of the proposed continuation program are: 1) to increase the scientific productivity in terms of peer reviewed publications by MBRS investigators from approximately four papers per three years (grant years 28-30) to an average of six papers per three years (grant years 32-34), and 2) to increase the acquisition of investigator initiated grants from 10% to 20% of the investigators associated with the SCORE program by year 34. ? ? This competing continuation application requests support for nineteen regular research projects and seven pilot projects. Projects are submitted from the School of Medicine departments of Anatomy and Physiology, Biochemistry, Family and Preventive Medicine, Microbiology, Pharmacology, and Psychiatry, as well as from the School of Dentistry. Thus the projects focus on a broad spectrum of health related issues including cancer, sickle cell disease, signaling and transduction mechanisms, oral health, infectious diseases including HIV/AIDS and neuroscience. Presently, the program includes eighteen regular projects. ? ?

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Minority Biomedical Research Support - MBRS (S06)
Project #
Application #
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Zlotnik, Hinda
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Meharry Medical College
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Pulliam, Stephanie R; Pellom Jr, Samuel T; Shanker, Anil et al. (2016) Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine 84:74-87
Chen, Chau-Kuang; Bruce, Michelle; Tyler, Lauren et al. (2013) Analysis of an environmental exposure health questionnaire in a metropolitan minority population utilizing logistic regression and Support Vector Machines. J Health Care Poor Underserved 24:153-71
Boadi, William Y; Harris, Shalandus; Anderson, Justin B et al. (2013) Lipid peroxides and glutathione status in human progenitor mononuclear (U937) cells following exposure to low doses of nickel and copper. Drug Chem Toxicol 36:155-62
Choudhury, Shahana A; Ladson, Gwinnett; Kabir, Madina S (2012) Evaluation of serotype-specific immunity to Streptococcus pneumoniae in pregnant women and cord blood of infants: impact of race and ethnicity. J Natl Med Assoc 104:251-7
Hall 3rd, Mack; Misra, Smita; Chaudhuri, Minu et al. (2011) Peptide aptamer mimicking RAD51-binding domain of BRCA2 inhibits DNA damage repair and survival in Trypanosoma brucei. Microb Pathog 50:252-62
Kawai, Yumiko; Garduño, Lakisha; Theodore, Melanie et al. (2011) Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 286:7629-40
Rana, Tanu; Misra, Smita; Mittal, Mukul K et al. (2011) Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania. J Biol Chem 286:6614-26
Farrow, Anitra L; Rana, Tanu; Mittal, Mukul K et al. (2011) Leishmania-induced repression of selected non-coding RNA genes containing B-box element at their promoters in alternatively polarized M2 macrophages. Mol Cell Biochem 350:47-57
Sharma, Shvetank; Singha, Ujjal K; Chaudhuri, Minu (2010) Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei. Mol Biochem Parasitol 174:89-100
Sheng, Liu; Ding, Xinxin; Ferguson, Marcus et al. (2010) Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci 118:625-34

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