Abstract

The main objective of our proposed project is to investigate charge transfer mechanism of proteins, nucletic acids and other model compounds. The investigators also plan to study photo- induced charge transfer processes at the interface between protein tissue and aromative hydrocarbons for the investigation of carcinogenesis. The heterogeneous charge transfer mechanism of redox proteins, such as horse heart cytochrome C (Cyt C) and ferredoxin will be examined at various electrodes. Electrochemical methods including cyclic voltammetry (CV), square wave voltammetry (SWV) and chronocoulometry Situ Raman spectroscopy will be utilized to obtain structural information of those protein molecules during the oxidation and reduction processes. Photo-induced charge transfer (or energy transfer) between proteins of tissue and aromatic hydrocarbons, such as perylene and fluoranthene will be investigated by fluorescence spectroscopy, as well a steady state fluorescence studies of the systems. This study may provide the information for the initiation reactions of carcinogenesis between aromatic mydrocarbons and protein tissue.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
3S06GM008047-20S1
Application #
3856225
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Jackson State University
Department
Type
DUNS #
044507085
City
Jackson
State
MS
Country
United States
Zip Code
39217

  Publications

Beqa, Lule; Fan, Zhen; Singh, Anant Kumar et al. (2011) Gold nano-popcorn attached SWCNT hybrid nanomaterial for targeted diagnosis and photothermal therapy of human breast cancer cells. ACS Appl Mater Interfaces 3:3316-24
Khan, Sadia Afrin; Singh, Anant K; Senapati, Dulal et al. (2011) Targeted highly sensitive detection of multi-drug resistant Salmonella DT104 using gold nanoparticles. Chem Commun (Camb) 47:9444-6
Singh, Anant K; Lu, Wentong; Senapati, Dulal et al. (2011) Long-range nanoparticle surface-energy-transfer ruler for monitoring photothermal therapy response. Small 7:2517-25
Huang, Yong; Zhao, Shulin; Shi, Ming et al. (2010) Chemiluminescent immunoassay of thyroxine enhanced by microchip electrophoresis. Anal Biochem 399:72-7
Wang, Shuguang; Singh, Anant K; Senapati, Dulal et al. (2010) Rapid colorimetric identification and targeted photothermal lysis of Salmonella bacteria by using bioconjugated oval-shaped gold nanoparticles. Chemistry 16:5600-6
Lu, Wentong; Singh, Anant Kumar; Khan, Sadia Afrin et al. (2010) Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy. J Am Chem Soc 132:18103-14
Lu, Wentong; Arumugam, Sri Ranjini; Senapati, Dulal et al. (2010) Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay. ACS Nano 4:1739-49
Dadiboyena, Sureshbabu; Valente, Edward J; Hamme 2nd, Ashton T (2010) Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates. Tetrahedron Lett 51:1341
Stewart, Gernerique; Smith, Keonia; Chornes, Ashley et al. (2010) PHOTOCHEMICAL REACTION OF NITRO-POLYCYCLIC AROMATIC HYDROCARBONS: EFFECT BY SOLVENT AND STRUCTURE. Environ Chem Lett 8:301-306
Zhao, Shulin; Huang, Yong; Shi, Ming et al. (2010) Chemiluminescence resonance energy transfer-based detection for microchip electrophoresis. Anal Chem 82:2036-41

Showing the most recent 10 out of 119 publications