The objectives of this program are to promote and support biomedical research at Tennessee State University and to encourage, direct and train minority students to become biomedical researchers. The program contains seven subprojects and two projects by associate investigators. This program proposes to support 15 faculty and 18 students to do research in cellular biology and in health problems in minority populations. The research undertaken focuses on two broad areas of concern: (1) molecular and cellular mechanisms of regulation and (2) health problems in minority populations. The first area will include studies such as (1) Study of drug binding to DNA in an effort to find better chemotherapeutic agents [Chen]; (2) Study of the effects of metals and other environmental pollutants on Acanthamoeba, an opportunistic human pathogen [Tomlinson]; (3) The effect os electromagnetic fields and UV radiation on mammalian cells [Alexander-Caudle and Myles]; (4) GABA mediated cardioregulation in Limulus [Newkirk, Blackshear and Washington]; (5) Phylogenetic and phenotypic variation in yeast killer factor [Ganter]. The second group of projects are concerned with health issues among minorities and include (1)Effects of passive smoke on children and young people [John and Parks]; (2) Value of AIDS education and intervention program to college freshman [Husaini]; (3) Use of an AIDS prevention program with minority women [Linn and Brown]; and (4) Development of a technique to identify and ablate arrhythmogenic foci [Ollapally]. These studies are designed to gain a better understanding of cellular and molecular events by which organisms regulate various functions. Further, problems and conditions on health are addressed which are of major importance in the U.S. population, and of particular relevance among minorities. This program emphasizes relevant research by TSU faculty and provides in depth training experiences for both undergraduate and graduate students.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Minority Biomedical Research Support - MBRS (S06)
Project #
Application #
Study Section
Minority Programs Review Committee (MPRC)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tennessee State University
Schools of Arts and Sciences
United States
Zip Code
Rana, Krupa; Whalen, Margaret (2015) Activation of protein kinase C and protein kinase D in human natural killer cells: effects of tributyltin, dibutyltin, and tetrabromobisphenol A. Toxicol Mech Methods 25:680-8
Hurd-Brown, Tasia; Udoji, Felicia; Martin, Tamara et al. (2013) Effects of DDT and triclosan on tumor-cell binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 33:495-502
Sharow, Kyle A; Temkin, Boris; Asson-Batres, Mary Ann (2012) Retinoic acid stability in stem cell cultures. Int J Dev Biol 56:273-8
Hurd, Tasia; Walker, Jasmine; Whalen, Margaret M (2012) Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 32:627-34
Taylor, Thyneice R; Whalen, Margaret M (2011) Ziram activates mitogen-activated protein kinases and decreases cytolytic protein levels in human natural killer cells. Toxicol Mech Methods 21:577-84
Buchanan, FaMitah Q; Rochette-Egly, Cecile; Asson-Batres, Mary Ann (2011) Detection of variable levels of RAR? and RAR? proteins in pluripotent and differentiating mouse embryonal carcinoma and mouse embryonic stem cells. Cell Tissue Res 346:43-51
Hurd, Tasia; Whalen, Margaret M (2011) Tetrabromobisphenol A decreases cell-surface proteins involved in human natural killer (NK) cell-dependent target cell lysis. J Immunotoxicol 8:219-27
Person, Rachel J; Whalen, Margaret M (2010) Effects of butyltin exposures on MAP kinase-dependent transcription regulators in human natural killer cells. Toxicol Mech Methods 20:227-33
Udoji, Felicia; Martin, Tamara; Etherton, Rachel et al. (2010) Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. J Immunotoxicol 7:205-12
Abraha, Abraham B; Rana, Krupa; Whalen, Margaret M (2010) Role of protein kinase C in TBT-induced inhibition of lytic function and MAPK activation in human natural killer cells. Arch Environ Contam Toxicol 59:661-9

Showing the most recent 10 out of 60 publications