Although several new projects are included in this proposal, the over-all major emphasis of our MBRS Program at Prairie View A&M University has not changed. The program continues to be designed to produce biomedical scientists and foster health related research and improve academics at this University. The late Dr. J. E. Berry, our former MBRS Director for over ten years, and Dr. Arthur Washington, our more recent past MBRS Director, set a tone of excellence in this program and it will be maintained. The projects included are 1) Recombinant Pseudotuberculosis Proteins for Vaccines and Diagnostic Reagents. 2) Synthesis of Benzo(c)phenanthridine derivatives. 3) Interactions of Fucoidan with Proteases, Activators and Inhibitors of Coagulation and Fibrinolysis. 4) Molecular and Immunological Analysis of Pasteurella Haemolytica RTX Toxin. 5) Dietary Fatty Acid Positional Distribution and Genetic Effects on Cholesterol Metabolism. 6) Cellular Basis for Pregnancy Recognition. 7)Amino Acid Carrier Characteristics of Mammalian Glutamyl Transpeptidase. and 8) Biological Implication of Milk Iron and Vitamins in Development of Anemias. In addition to research activities in the School of Arts and Sciences, the establishment of a modern """"""""State of the Art"""""""" Cooperative Agriculture Research Center (CARC) at the University has added new stimulus for basic research. A great deal of collaborative research activities between the Natural Sciences and CARC have occurred. Also seminars for MBRS participants and research scientists at CARC have provided an opportunity for students and faculty to present their research and discuss possible solutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008094-23
Application #
2444417
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1978-06-01
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
23
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Prairie View Agri & Mech University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
008730355
City
Prairie View
State
TX
Country
United States
Zip Code
77446
Kouemo, Stella; McMillan, Erinn; Doctor, Vasant (2010) Mechanism of the synergistic effect between oversulfated chondroitin-6-sulfate and lysine or 6-aminohexanoic acid in enhancing the in-vitro activation of glutamic plasminogen by tissue plasminogen activator or urokinase. Blood Coagul Fibrinolysis 21:425-30
Woldesenbet, S; Garcia, R; Igbo, N et al. (2004) Lectin receptors for endometrial H-type 1 antigen on goat conceptuses. Am J Reprod Immunol 52:74-80
Woldesenbet, S; Newton, G R (2003) Comparison of proteins synthesized by polarized caprine oviductal epithelial cells and oviductal explants in vitro. Theriogenology 60:533-43
Woldesenbet, S; Green, T; Newton, G R (2002) H-Type 1 carbohydrate antigen expression by ovine endometrial cells. In Vitro Cell Dev Biol Anim 38:358-64
Powell, J K; Glasser, S R; Woldesenbet, S et al. (2000) Expression of carbohydrate antigens in the goat uterus during early pregnancy and on steroid-treated polarized uterine epithelial cells in vitro. Biol Reprod 62:277-84
Newton, G R; Weise, D W; Bowen, J A et al. (1998) Regulation of protein and prostaglandin secretion in polarized primary cultures of caprine uterine epithelial cells. In Vitro Cell Dev Biol Anim 34:578-84
Burghardt, R C; Bowen, J A; Newton, G R et al. (1997) Extracellular matrix and the implantation cascade in pigs. J Reprod Fertil Suppl 52:151-64
Smith, E E; Duffus, E A; Small, M H (1993) Effects of patulin on postimplantation rat embryos. Arch Environ Contam Toxicol 25:267-70