Biologically Active Small Cage Boron Compounds

Onak, Thomas P.

Abstract

Biologically active derivatives of small cage boron hydride moieties, to be used in chemotherapy, will be synthesized. The emphasis will be on the synthesis of polyboranes containing a nitrogen attachment similar to those that have already shown confirmed activity against the leukemia P-388 test system. Functionalities will be introduced onto promising molecules in attempts to change the lipid solubilities of these systems. Structural relationships of boron compounds will be correlated to anticancer activity and other medicinal applications. Both of the two undergraduates and the graduate student, as well as the principal investigator, will carry out laboratory research projects to accomplish these goals.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Minority Biomedical Research Support - MBRS (S06)
• Project #: 5S06GM008101-19
• Application #: 3877315
• Support Year: 19
• Fiscal Year: 1990

Institution

• Name: California State University Los Angeles
• City: Los Angeles
• State: CA
• Country: United States
• Zip Code: 90032

Publications

Durvasula, Ramani S (2017) Personality Disorders and Health: Lessons Learned and Future Directions. Behav Med 43:227-232

Crespo, Noe C; Yoo, Eun Jung; Hawkins, Steven A (2011) Anthropometric and lifestyle associations of bone mass in healthy pre-menopausal Mexican and Asian American women. J Immigr Minor Health 13:74-80

Kumar, Satish; Velasco, Kriya; McCurdy, Alison (2010) X-ray, kinetics and DFT studies of photochromic substituted benzothiazolinic spiropyrans. J Mol Struct 968:13-18

Jiang, Dianlu; Li, Xiangjun; Williams, Renee et al. (2009) Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease. Biochemistry 48:7939-47

Pech, Herbe; Henry, Amanda; Khachikian, Crist S et al. (2009) Detection of geothermal phosphite using high-performance liquid chromatography. Environ Sci Technol 43:7671-5

Jiang, Dianlu; Dinh, Kim Lien; Ruthenburg, Travis C et al. (2009) A kinetic model for beta-amyloid adsorption at the air/solution interface and its implication to the beta-amyloid aggregation process. J Phys Chem B 113:3160-8

Hong, Hyun-Seok; Rana, Sandeep; Barrigan, Lydia et al. (2009) Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. J Neurochem 108:1097-1108

Kumar, Satish; Chau, Cindy; Chau, Gordan et al. (2008) Synthesis and metal complexation properties of bisbenzospiropyran chelators in water. Tetrahedron 64:7097-7105

Kumar, Satish; Hernandez, David; Hoa, Brenda et al. (2008) Synthesis, photochromic properties, and light-controlled metal complexation of a naphthopyran derivative. Org Lett 10:3761-4

Valentine, Sonya C; Contreras, Deisy; Tan, Stephanie et al. (2008) Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California. J Clin Microbiol 46:2499-507