The chemistry of metal-dithiolate complexes and metal disulfide complexes will be studied as model systems for metallo-thiolate electron transport proteins such as the ubiquitous iron-sulfur proteins. It is proposed that these metalloproteins can obtain additional reducing power by the formation partial S.S bonds through interaction of two adjacent metal-bound thiolates. Evidence for this hypothesis comes from a number of examples of metal-thiolate complexes where the S.S separations are considerably smaller than the predicted nearest neighbor contact of non-bonded sulfur atoms. Metallosulfur complexes will be synthesized where the dithiolate/disulfide couple is reversible. Dithiolate complexes will be prepared with high-valent metal ions while disulfide complexes will be prepared with low-valent metal ions. The oxidation of the thiolate complexes and the reduction of the disulfide complexes will be studied in order to provide further evidence for the dithiolate/disulfide couple serving as a source of increased reducing power in electron transfer proteins.

Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1990
Total Cost
Indirect Cost
Name
California State University Los Angeles
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90032
Durvasula, Ramani S (2017) Personality Disorders and Health: Lessons Learned and Future Directions. Behav Med 43:227-232
Crespo, Noe C; Yoo, Eun Jung; Hawkins, Steven A (2011) Anthropometric and lifestyle associations of bone mass in healthy pre-menopausal Mexican and Asian American women. J Immigr Minor Health 13:74-80
Kumar, Satish; Velasco, Kriya; McCurdy, Alison (2010) X-ray, kinetics and DFT studies of photochromic substituted benzothiazolinic spiropyrans. J Mol Struct 968:13-18
Jiang, Dianlu; Li, Xiangjun; Williams, Renee et al. (2009) Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease. Biochemistry 48:7939-47
Pech, Herbe; Henry, Amanda; Khachikian, Crist S et al. (2009) Detection of geothermal phosphite using high-performance liquid chromatography. Environ Sci Technol 43:7671-5
Jiang, Dianlu; Dinh, Kim Lien; Ruthenburg, Travis C et al. (2009) A kinetic model for beta-amyloid adsorption at the air/solution interface and its implication to the beta-amyloid aggregation process. J Phys Chem B 113:3160-8
Hong, Hyun-Seok; Rana, Sandeep; Barrigan, Lydia et al. (2009) Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. J Neurochem 108:1097-1108
Kumar, Satish; Chau, Cindy; Chau, Gordan et al. (2008) Synthesis and metal complexation properties of bisbenzospiropyran chelators in water. Tetrahedron 64:7097-7105
Kumar, Satish; Hernandez, David; Hoa, Brenda et al. (2008) Synthesis, photochromic properties, and light-controlled metal complexation of a naphthopyran derivative. Org Lett 10:3761-4
Valentine, Sonya C; Contreras, Deisy; Tan, Stephanie et al. (2008) Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California. J Clin Microbiol 46:2499-507

Showing the most recent 10 out of 42 publications