Evidence from numerous studies support the theory that-human cancers and respiratory illnesses can be caused by environmental pollution. There is a good correlation between regions with a high incidence of cancer and respiratory illnesses and high levels of air pollution. It is suspect that even moderate levels of air pollution can increase the risk of detrimental health effects. Biotesting of the organic fraction of atmospheric particulate has shown mutagenic and carcinogenic activity. However there is much uncertainty in trying to attribute specific health effects to air pollution due to variations in environment, exposure and the population. A study which could show atmospheric pollutants in the human body will lend direct evidence to the theory. The purpose of this project is to determine if organic atmospheric pollutants can deposit and accumulate in lipid tissues. Analytical methodology capable of detecting a broad spectrum of compounds will first be optimized for gaseous samples, particulate samples and lipid tissues. The air at two locations, each the site of a monkey colony, will be characterized over time. One site is relatively pollution free while the other has significant levels of air pollution. Correlation between the compounds found in the air samples and those in the lipid tissues could give direct evidence that environmental compounds could affect human health.

Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Puerto Rico Rio Piedras
Department
Type
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00931
Ramírez-Camejo, Luis A; Maldonado-Morales, Génesis; Bayman, Paul (2017) Differential Microbial Diversity in Drosophila melanogaster: Are Fruit Flies Potential Vectors of Opportunistic Pathogens? Int J Microbiol 2017:8526385
Morales-Rivera, Keyla F; Piñero Cruz, Dalice M; Prieto, Jose A (2017) Crystal structure of (-)-(S)-4-[(2S,3S,4S,Z)-3-hydroxy-4-methyl-hept-5-en-2-yl]-1,3-dioxolan-2-one. Acta Crystallogr E Crystallogr Commun 73:1070-1072
García-Arriaga, Marilyn; Acosta-Santiago, Maxier; Cruz, Antony et al. (2017) Probing the Limits of Supramolecular G-Quadruplexes Using Atomistic Molecular Dynamics Simulations. Inorganica Chim Acta 468:209-222
Huang, Qing; Quiñones, Edwin (2016) A spectroscopic method to determine the activity of the restriction endonuclease EcoRV that involves a single reaction. Anal Biochem 497:103-5
Mège, Pascal; Schizas, Nikolaos V; Reyes, Joselyd García et al. (2015) Genetic seascape of the threatened Caribbean elkhorn coral, Acropora palmata, on the Puerto Rico Shelf. Mar Ecol (Berl) 36:195-209
Morales-Rivera, Amarilys; Hernández-Burgos, Mayté M; Martínez-Rivera, Arlene et al. (2014) Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats. Psychopharmacology (Berl) 231:4145-55
Ramírez-Camejo, Luis A; Torres-Ocampo, Ana P; Agosto-Rivera, José L et al. (2014) An opportunistic human pathogen on the fly: strains of Aspergillus flavus vary in virulence in Drosophila melanogaster. Med Mycol 52:211-9
Galindo-Cardona, Alberto; Acevedo-Gonzalez, Jenny P; Rivera-Marchand, Bert et al. (2013) Genetic structure of the gentle Africanized honey bee population (gAHB) in Puerto Rico. BMC Genet 14:65
Santiago-Rodriguez, Tasha M; Rivera, Jessica I; Coradin, Mariel et al. (2013) Antibiotic-resistance and virulence genes in Enterococcus isolated from tropical recreational waters. J Water Health 11:387-96
Pantoja-Feliciano, Ida Gisela; Clemente, Jose C; Costello, Elizabeth K et al. (2013) Biphasic assembly of the murine intestinal microbiota during early development. ISME J 7:1112-5

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