Mathematical models have contributed to many of the basic ideas leading to our current understanding of the urinary concentrating mechanism. However, these models have been unable to generate any significant concentration gradient in the inner medulla when experimentally measured parameter values are used. The long-term objective of this project is to develop comprehensive mathematical models for the urine concentrating mechanism in mammalian kidney.
The specific aims of this pilot project are: to explore the typical experimental parameter space by formulating and numerically solving inverse problems for one-dimensional models; and to systematically evaluate and justify more rigorously the model simplifying assumptions by formulating models in two or three dimensions for isolated tubules, in which the simplifying assumptions of the one-dimensional models can be removed.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008102-35
Application #
7261282
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
35
Fiscal Year
2006
Total Cost
$35,000
Indirect Cost
Name
University of Puerto Rico Rio Piedras
Department
Type
DUNS #
143960193
City
San Juan
State
PR
Country
United States
Zip Code
00931
Ramírez-Camejo, Luis A; Maldonado-Morales, Génesis; Bayman, Paul (2017) Differential Microbial Diversity in Drosophila melanogaster: Are Fruit Flies Potential Vectors of Opportunistic Pathogens? Int J Microbiol 2017:8526385
Morales-Rivera, Keyla F; Piñero Cruz, Dalice M; Prieto, Jose A (2017) Crystal structure of (-)-(S)-4-[(2S,3S,4S,Z)-3-hydroxy-4-methyl-hept-5-en-2-yl]-1,3-dioxolan-2-one. Acta Crystallogr E Crystallogr Commun 73:1070-1072
García-Arriaga, Marilyn; Acosta-Santiago, Maxier; Cruz, Antony et al. (2017) Probing the Limits of Supramolecular G-Quadruplexes Using Atomistic Molecular Dynamics Simulations. Inorganica Chim Acta 468:209-222
Huang, Qing; Quiñones, Edwin (2016) A spectroscopic method to determine the activity of the restriction endonuclease EcoRV that involves a single reaction. Anal Biochem 497:103-5
Mège, Pascal; Schizas, Nikolaos V; Reyes, Joselyd García et al. (2015) Genetic seascape of the threatened Caribbean elkhorn coral, Acropora palmata, on the Puerto Rico Shelf. Mar Ecol (Berl) 36:195-209
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Ramírez-Camejo, Luis A; Torres-Ocampo, Ana P; Agosto-Rivera, José L et al. (2014) An opportunistic human pathogen on the fly: strains of Aspergillus flavus vary in virulence in Drosophila melanogaster. Med Mycol 52:211-9
Galindo-Cardona, Alberto; Acevedo-Gonzalez, Jenny P; Rivera-Marchand, Bert et al. (2013) Genetic structure of the gentle Africanized honey bee population (gAHB) in Puerto Rico. BMC Genet 14:65
Santiago-Rodriguez, Tasha M; Rivera, Jessica I; Coradin, Mariel et al. (2013) Antibiotic-resistance and virulence genes in Enterococcus isolated from tropical recreational waters. J Water Health 11:387-96
Pantoja-Feliciano, Ida Gisela; Clemente, Jose C; Costello, Elizabeth K et al. (2013) Biphasic assembly of the murine intestinal microbiota during early development. ISME J 7:1112-5

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