Abstract

The overall goal of this research is to study the mechanism of light energy transduction in visual pigments and related pigments using resonance Raman spectroscopy. This technique is a very powerful one to probe the structure and changes in structure of the visual pigment retinal chromophore that accompany the early stages of vision. The ultimate goal is to understand from a molecular viewpoint how light energy is converted to that chemistry that is called visual transduction. Transduction processes are important problems in biology, and a molecular understanding of the visual system is an important step. Three main areas of study are envisioned. Experiments are planned to elucidate the nature of the chromophoric site. The structure of the primary photoproducts are to be measured so as to understand how light energy is converted to chemical energy. Lastly, dark intermediates and reaction pathways are to be probed to help elucidate how this chemical energy is used.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
2S06GM008168-15
Application #
3777987
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
City College of New York
Department
Type
DUNS #
603503991
City
New York
State
NY
Country
United States
Zip Code
10031

  Publications

Fried, Eric S; Li, Yue-Ming; Gilchrist, M Lane (2017) Phase Composition Control in Microsphere-Supported Biomembrane Systems. Langmuir 33:3028-3039
Gilchrist, M Lane; Ahn, Kwangwook; Li, Yue-Ming (2016) Imaging and Functional Analysis of ?-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe. Anal Chem 88:1303-11
Fried, Eric S; Luchan, Joshua; Gilchrist, M Lane (2016) Biodegradable, Tethered Lipid Bilayer-Microsphere Systems with Membrane-Integrated ?-Helical Peptide Anchors. Langmuir 32:3470-5
Banerjee, Shaibal; Sinha, Saikat; Pradhan, Padmanava et al. (2016) Regiospecifically Fluorinated Polycyclic Aromatic Hydrocarbons via Julia-Kocienski Olefination and Oxidative Photocyclization. Effect of Fluorine Atom Substitution on Molecular Shape. J Org Chem 81:3983-93
Beck, Cade; Singh, Tanya; Farooqi, Angela et al. (2016) Controlled microfluidics to examine growth-factor induced migration of neural progenitors in the Drosophila visual system. J Neurosci Methods 262:32-40
Salas-Ramirez, Kaliris Y; Bagnall, Ciara; Frias, Leslie et al. (2015) Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways. Behav Brain Res 292:133-41
Thomson, Paul F; Parrish, Damon; Pradhan, Padmanava et al. (2015) Modular, Metal-Catalyzed Cycloisomerization Approach to Angularly Fused Polycyclic Aromatic Hydrocarbons and Their Oxidized Derivatives. J Org Chem 80:7435-46
Small, Chiyedza; Ramroop, Johnny; Otazo, Maria et al. (2014) An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila. Genetics 197:471-83
De Waal, Eric M; Liang, Hanyu; Pierce, Anson et al. (2013) Elevated protein carbonylation and oxidative stress do not affect protein structure and function in the long-living naked-mole rat: a proteomic approach. Biochem Biophys Res Commun 434:815-9
Wise, Alexandria; Schatoff, Emma; Flores, Julian et al. (2013) Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion. Int J Dev Neurosci 31:624-33

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