Application): Members of one family of larger foraminifera, the Soritidae, are the hosts for a wide variety of unicellular endosymbiotic algae. It is reasonable to speculate that they have some symbiotic recognition and maintenance systems in common, and some of which are more specific. One interpretation is that, over time, the hosts an symbionts have maintained wide flexible relationships. This idea is contrary to a paradigm derived from studies of terminates and their parabasalian endosymbionts, which suggest that hosts and symbionts co-evolved. The investigator has identified an interesting evolutionary and systemic problem that suggests an alternative symbiotic evolutionary pathway that has potential for probing in the laboratory for probing in the laboratory. The study has the potential to show that a system of host/symbiont relationships that are not finical could have advantages for survival and adaptation in changing habitats. Tests of the speculation that soritid foraminifera acquire(d) dinoflagellate endosymbionts from environmental pools contributed to by coelenterates in their habitat are proposed.
The aims of this proposal are: (1) to analyze the dinoflagellate species structure in populations of soritid larger foraminifera; (2) to compare the foraminiferal dinoflagellate endosymbiont species at collection sites with those of nearby corals and other invertebrates; and (3) to search for common surface antigens which may be involved in the initial signaling process and maintenance. Since this aspect of cellular evolution is highly developed in foraminifera, it is hoped that they will provide rich new models for the study of molecular interactions between phagotrophic unicellular eukaryotes and prey which has developed the ability to escape digestion.
|Fried, Eric S; Li, Yue-Ming; Gilchrist, M Lane (2017) Phase Composition Control in Microsphere-Supported Biomembrane Systems. Langmuir 33:3028-3039|
|Gilchrist, M Lane; Ahn, Kwangwook; Li, Yue-Ming (2016) Imaging and Functional Analysis of ?-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe. Anal Chem 88:1303-11|
|Fried, Eric S; Luchan, Joshua; Gilchrist, M Lane (2016) Biodegradable, Tethered Lipid Bilayer-Microsphere Systems with Membrane-Integrated ?-Helical Peptide Anchors. Langmuir 32:3470-5|
|Banerjee, Shaibal; Sinha, Saikat; Pradhan, Padmanava et al. (2016) Regiospecifically Fluorinated Polycyclic Aromatic Hydrocarbons via Julia-Kocienski Olefination and Oxidative Photocyclization. Effect of Fluorine Atom Substitution on Molecular Shape. J Org Chem 81:3983-93|
|Beck, Cade; Singh, Tanya; Farooqi, Angela et al. (2016) Controlled microfluidics to examine growth-factor induced migration of neural progenitors in the Drosophila visual system. J Neurosci Methods 262:32-40|
|Salas-Ramirez, Kaliris Y; Bagnall, Ciara; Frias, Leslie et al. (2015) Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways. Behav Brain Res 292:133-41|
|Thomson, Paul F; Parrish, Damon; Pradhan, Padmanava et al. (2015) Modular, Metal-Catalyzed Cycloisomerization Approach to Angularly Fused Polycyclic Aromatic Hydrocarbons and Their Oxidized Derivatives. J Org Chem 80:7435-46|
|Small, Chiyedza; Ramroop, Johnny; Otazo, Maria et al. (2014) An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila. Genetics 197:471-83|
|Zhong, Lina; Tu, Raymond; Gilchrist, M Lane (2013) Tether-supported biomembranes with ?-helical peptide-based anchoring constructs. Langmuir 29:299-307|
|Guleyupoglu, Berkan; Schestatsky, Pedro; Edwards, Dylan et al. (2013) Classification of methods in transcranial electrical stimulation (tES) and evolving strategy from historical approaches to contemporary innovations. J Neurosci Methods 219:297-311|
Showing the most recent 10 out of 94 publications