Abstract

The Minority Biomedical Support Program at SUNY/Old Westbury includes five subprojects: 1) Development of synthetic procedures for preparation of biologically important compounds related to cholesterol and steroid hormones. 2) Exploration of the potential of biologically active compounds from marine bryozoans and their effects on both prokaryote and eukaryote cells. 3) A study of the functional relationship between processing and secretion of procollagen in chick embryo tendon culture. The various stages of pro-collagen processing as procollagen is secreted from the cells is being determined. 4) Preparation of organic semiconducting polymers which have transition metals in alternating mixed oxidation states along the chain. This construction will serve as a paradigm for electron transfer in biological reactions. 5) A study of the rates and mechanisms of electron-transfer reactions in solution. The Minority Biomedical Support Program at Old Westbury provides undergraduate students with research experience.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008180-11
Application #
3513452
Study Section
General Research Support Review Committee (GRS)
Project Start
1980-06-01
Project End
1991-05-31
Budget Start
1990-06-01
Budget End
1991-05-31
Support Year
11
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
College at Old Westbury
Department
Type
Schools of Arts and Sciences
DUNS #
City
Old Westbury
State
NY
Country
United States
Zip Code
11568

  Publications

Wang, Qiang; Fong, Robert; Mason, Peggy et al. (2014) Caffeine accelerates recovery from general anesthesia. J Neurophysiol 111:1331-40
Colaneri, Michael J; Vitali, Jacqueline; Kirschbaum, Kristin (2013) Electron paramagnetic resonance spectroscopic study of copper hopping in doped bis(L-histidinato)cadmium dihydrate. J Phys Chem A 117:3414-27
Colaneri, Michael J; Vitali, Jacqueline; Peisach, Jack (2009) Aspects of structure and bonding in copper-amino acid complexes revealed by single-crystal EPR/ENDOR spectroscopy and density functional calculations. J Phys Chem A 113:5700-9
Vitali, Jacqueline; Colaneri, Michael J (2008) Structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase in an orthorhombic crystal form. Acta Crystallogr Sect F Struct Biol Cryst Commun 64:776-80
Colaneri, M J; Vitali, J; Peisach, J (2000) Electron spin-echo envelope modulation study of multicrystalline Cu(2+)-insulin: effects of Cd(2+) on the nuclear quadrupole interaction of the Cu(2+)-coordinated imidazole remote nitrogen. Biochemistry 39:584-91
Leung, M K (1994) Biochemical isolation and detection of morphine. Adv Neuroimmunol 4:93-103
Hoyte, R M; Borderon, K; Bryson, K et al. (1994) Synthesis and evaluation of 7 alpha-iodo-5 alpha-dihydrotestosterone as a potential radioligand for androgen receptor. J Med Chem 37:1224-30
Golub, L M; Wolff, M; Roberts, S et al. (1994) Treating periodontal diseases by blocking tissue-destructive enzymes. J Am Dent Assoc 125:163-9;discussion 169-71
Yu, Z; Ramamurthy, N S; Leung, M et al. (1993) Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: a dose-response study. J Periodontal Res 28:420-8
Hoyte, R M; Brown, T J; MacLusky, N J et al. (1993) 7 alpha-Methyl-17 alpha-(E-2'-[125I]iodovinyl)-19-nortestosterone: a new radioligand for the detection of androgen receptor. Steroids 58:13-23

Showing the most recent 10 out of 13 publications