These proposals are written to extend the Biomedical Research Initiation at UAPB, whereby more students will be exposed to biomedical research experiences in biology, chemistry, and psychology. These experiences will be used for future endeavors. Knowledge will be gained in critical analytical thinking, separation of components, research techniques, report writing, literature searches, presentation of seminars, and instrumental skills. These proposals will improve the quality of education at UAPB and prepare students for graduate schools and research careers. Students will also receive financial assistance in working in a scientific situation of interest. These experiences acquired are generally quite different from those in """"""""cookbook"""""""" procedures. They will also serve to attract students to biomedical research and make them more competitive. The following projects are included: (1) Development of a Sensitive HPLC Method to Detect Aflatoxins B1, B2, G1, G2, M1, and M2; (2) Information Processing in the Mentally Retarded: Integrated and Asymmetric Brain Activities; (3) Investigations of Oxazolidines as Potential Pro-drugs for Ephedrine and Pseudoephedrine; (4) Studies in Benzopyran Derivatives; (5) Antineoplasic Copper(II) and Manganese(II) Salicylates and Copper(II) Acetylsalicylates; (6) The Effects of Fluoride on Brain Aluminum Concentration in Rats; and (7) Stress Management in College Students.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008211-08
Application #
3513516
Study Section
General Research Support Review Committee (GRS)
Project Start
1983-09-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Arkansas at Pine Bluff
Department
Type
Schools of Arts and Sciences
DUNS #
City
Pine Bluff
State
AR
Country
United States
Zip Code
71601
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Walker, R B; Dholakia, V N; Brasfield, K L et al. (1998) Effect of hydroxypropyl-beta-cyclodextrin on the central stimulant activity of (-)-ephedrine and an oxazolidine prodrug in rats. Gen Pharmacol 30:725-31
Bakhtiar, R; Hop, C E; Walker, R B (1997) Effect of cyclodextrins on the hydrolysis of an oxazolidine prodrug of (1R,2S)-(-)-ephedrine-cis-2-(4-methoxyphenyl)-3, 4-dimethyl-5-phenyloxazolidine. Rapid Commun Mass Spectrom 11:598-602
Walker, R B; Fitz, L D; Williams, L M et al. (1996) The effect on ephedrine prodrugs on locomotor activity in rats. Gen Pharmacol 27:109-11
Walker, R B; Wood, D M; Akmal, M M et al. (1992) Effects of oxazolidines derived from (-) ephedrine in the rat. Gen Pharmacol 23:729-32
Walker, R B; Wood, D M; Akmal, M M (1990) Hyperthermic and anorectic effects of oxazolidines derived from L-ephedrine in rats. Life Sci 47:595-600