Abstract

The red blood cell (RBC) transfusion """"""""trigger"""""""" has been used to refer to the minimum hemoglobin (Hb) of hematocrit (Hct) values or the clinical sign or symptom at which a RBC transfusion should administered. The RBC transfusion triggers involving clinical signs or symptoms in anemic neonates and apnea. Because RBC transfusions are expensive and are not without risk, the development of accurate and sensitive triggers is needed to improve clinical decisions regarding the need to transfuse. The purpose of this research is to determine the potential utility of using auditory brainstem responses neonates. These electrophysiologic tests objectively examine the integrity of the auditory nervous system and therefore may be sensitive to any anemic changes that impair its normal function. The experimental protocol includes an examination of both an animal and human model. Sheep were chosen as the experimental because of their extensive use in perinatal and development physiology for both sheep and pre-term neonates along with the corresponding ABR and DPE recordings. A correlation between different degrees of anemia and any changes in ABRs and DPEs, which may reflect auditory nervous system impair, will be examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
2S06GM008224-16
Application #
6404603
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1985-05-01
Project End
2004-07-31
Budget Start
Budget End
Support Year
16
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of Puerto Rico Med Sciences
Department
Type
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00936

  Publications

Rijpma, Sanna R; van der Velden, Maarten; González-Pons, Maria et al. (2016) Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites. Cell Microbiol 18:369-83
Padín-Irizarry, Vivian; Colón-Lorenzo, Emilee E; Vega-Rodríguez, Joel et al. (2016) Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage. Free Radic Biol Med 95:43-54
Jardón, Javier; Izquierdo, Natalio J; Renta, Jessica Y et al. (2016) Ocular Findings in Patients with the Hermansky-Pudlak Syndrome (Types 1 and 3). Ophthalmic Genet 37:89-94
Rivera-Peña, Bianca; Ruíz-Fullana, Francisco J; Vélez-Reyes, Germán L et al. (2016) HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients. Infect Agent Cancer 11:47
Velásquez-Martínez, Maria C; Vázquez-Torres, Rafael; Rojas, Legier V et al. (2015) Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology 88:110-21
Vega-Rodríguez, Joel; Pastrana-Mena, Rebecca; Crespo-Lladó, Keila N et al. (2015) Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin. PLoS One 10:e0128212
Zenón, Frances; Cantres-Rosario, Yisel; Adiga, Radhika et al. (2015) HIV-infected microglia mediate cathepsin B-induced neurotoxicity. J Neurovirol 21:544-58
Ortiz, A P; Unger, E R; Muñoz, C et al. (2014) Cross-sectional study of HPV-16 infection in a population-based subsample of Hispanic adults. BMJ Open 4:e004203
Rosas, Odrick R; Torrado, Aranza I; Santiago, Jose M et al. (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Neural Regen Res 9:2164-73
Mosquera, Laurivette; Colón, Jennifer M; Santiago, José M et al. (2014) Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. Brain Res 1561:11-22

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