The overall aim of the MBRS Support of Continuous Research Excellence (SCORE) Program at the MSC-UPR is to? assist faculty to develop competitive research programs, and to increase the number of underrepresented minorities? professionally engaged in biomedical, clinical and behavioral research. Goal 1 of the proposed program aims to? increase the scholarly and scientific productivity of MSC investigators. Specific objectives of this goal target? outcome measurable increases by MBRS SCORE researchers in: the quantity of publications in peer-reviewed journals? (Specific Objective 1.1); the number of presentations (Specific Objective 1.2), with most of this growth occurring in? national or international forums; the submission and awarding of investigator-initiated grant applications (i.e. R-type,? and NSF) (Specific Objective 1.3); the scientific network of supported investigators, by establishing a mentor and/or a? collaborative relationship with a scientists in the area of their research expertise (Specific Objective 1.4); and, in the? yearly progress towards completing the specific aims of each research project (Specific Objective 1.5). Goal 2 seeks to? coordinate the faculty research activities of the MBRS-SCORE with the student, faculty, and institutional? development activities of the MBRS-RISE. Its specific objective is to provide to a minimum of two students? (graduate or undergraduate) per year the opportunity to actively participate in research in the funded MBRS SCORE? laboratories. And Goal 3 will enhance the research environment and infrastructure of the MBRS SCORE to? support the projected increased research activity and productivity of the faculty. In specific we propose to? establish an MBRS-SCORE sponsored Seminar Series (Specific Objective 3.1), in topics germane to the research? interest of SCORE Program investigators; and, maintain continuous support of the Molecular Biology CORE Lab? facilities by continuing to provide access to research-support personnel (Specific Objective 3.2). The 25 projects (20? regular and 5 pilot) being submitted as part of the program include basic and clinical biomedically related research? projects from faculty in the Schools of Medicine, Public Health, Pharmacy, and Allied Health Professions. The? proposed MBRS SCORE Program in its configuration unites a cadre of investigators from areas such as molecular? biology, biochemistry, physiology, anatomy, cell biology; microbiology, immunology, neurobiology congenital? malformations, pharmaceutical sciences, and epidemiology and biostatistics. Their individual and combined efforts? address a vast army of health conditions that primarily disproportionately affect minorities, such as: genetic disorders,? HIV, Hepatitis C, mental depression, asthma, dengue, malaria, and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
3S06GM008224-23S2
Application #
7663467
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Toliver, Adolphus
Project Start
1985-05-01
Project End
2009-07-31
Budget Start
2007-08-01
Budget End
2009-07-31
Support Year
23
Fiscal Year
2008
Total Cost
$825,000
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Rijpma, Sanna R; van der Velden, Maarten; González-Pons, Maria et al. (2016) Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites. Cell Microbiol 18:369-83
Padín-Irizarry, Vivian; Colón-Lorenzo, Emilee E; Vega-Rodríguez, Joel et al. (2016) Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage. Free Radic Biol Med 95:43-54
Jardón, Javier; Izquierdo, Natalio J; Renta, Jessica Y et al. (2016) Ocular Findings in Patients with the Hermansky-Pudlak Syndrome (Types 1 and 3). Ophthalmic Genet 37:89-94
Rivera-Peña, Bianca; Ruíz-Fullana, Francisco J; Vélez-Reyes, Germán L et al. (2016) HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients. Infect Agent Cancer 11:47
Velásquez-Martínez, Maria C; Vázquez-Torres, Rafael; Rojas, Legier V et al. (2015) Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology 88:110-21
Vega-Rodríguez, Joel; Pastrana-Mena, Rebecca; Crespo-Lladó, Keila N et al. (2015) Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin. PLoS One 10:e0128212
Zenón, Frances; Cantres-Rosario, Yisel; Adiga, Radhika et al. (2015) HIV-infected microglia mediate cathepsin B-induced neurotoxicity. J Neurovirol 21:544-58
Rosas, Odrick R; Torrado, Aranza I; Santiago, Jose M et al. (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Neural Regen Res 9:2164-73
Mosquera, Laurivette; Colón, Jennifer M; Santiago, José M et al. (2014) Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. Brain Res 1561:11-22
Hodakoski, Cindy; Hopkins, Benjamin D; Barrows, Douglas et al. (2014) Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A 111:155-60

Showing the most recent 10 out of 174 publications