Abstract

Among methods under active study for curative cancer therapy is the use of labeled monoclonal antibodies directed against tumor- specific or tumor-associated antigens. The efficacy of such strategies can be accurately modeled using computer programs involving compartmental analysis. Two major components of this treatment can be developed with our models: 1. The dosimetry resulting from the circulation and localization of the labeled antibodies. This dosimetry investigation is essential to the development and approval of clinical protocols. 2. The optimization of the localization of the activity through time- dependent infusion of the antibodies. Future studies to be undertaken during the period of the grant include modeling for magnetic resonant imaging (NMR) studies of the evolution of cerebral circulation during the course of radiation therapy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008225-06
Application #
3877672
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Herbert H. Lehman College
Department
Type
DUNS #
620128301
City
New York
State
NY
Country
United States
Zip Code
10468

  Publications

Zheng, Zhi-Liang (2017) Ras and Rho GTPase regulation of Pol II transcription: A shortcut model revisited. Transcription 8:268-274
Zhang, Bo; Yang, Guohua; Chen, Yu et al. (2016) C-terminal domain (CTD) phosphatase links Rho GTPase signaling to Pol II CTD phosphorylation in Arabidopsis and yeast. Proc Natl Acad Sci U S A 113:E8197-E8206
Guerrero-Berroa, Elizabeth; Kluger, Alan; Schmeidler, James et al. (2014) Neuropsychological and neuropsychiatric prediction of global cognitive status among older Spanish-speaking Hispanics and English-speaking whites. J Geriatr Psychiatry Neurol 27:266-75
Zhang, Bo; Pasini, Rita; Dan, Hanbin et al. (2014) Aberrant gene expression in the Arabidopsis SULTR1;2 mutants suggests a possible regulatory role for this sulfate transporter in response to sulfur nutrient status. Plant J 77:185-97
Sailor, Kevin; Brooks, Patricia J (2014) Do part-whole relations produce facilitation in the picture-word interference task? Q J Exp Psychol (Hove) 67:1768-85
Gharbaran, Rajendra; Alvarado, Susana; Aisemberg, Gabriel O (2014) Regional and segmental differences in the embryonic expression of a putative leech Hox gene, Lox2, by central neurons immunoreactive to FMRFamide-like neuropeptides. Invert Neurosci 14:51-8
Gharbaran, Rajendra; Aisemberg, Gabriel O (2013) Identification of leech embryonic neurons that express a Hox gene required for the differentiation of a paired, segment-specific motor neuron. Int J Dev Neurosci 31:105-15
Gharbaran, Rajendra; Aisemberg, Gabriel O; Alvarado, Susana (2012) Segmental and regional differences in neuronal expression of the leech Hox genes Lox1 and Lox2 during embryogenesis. Cell Mol Neurobiol 32:1243-53
Yang, Hui; Figueroa, Mario; To, Satoshi et al. (2010) Benzophenones and biflavonoids from Garcinia livingstonei fruits. J Agric Food Chem 58:4749-55
Vallabhaneni, Ratnakar; Bradbury, Louis M T; Wurtzel, Eleanore T (2010) The carotenoid dioxygenase gene family in maize, sorghum, and rice. Arch Biochem Biophys 504:104-11

Showing the most recent 10 out of 67 publications