Paranasal sinuses, or air spaces, are a prominent feature of the modern human face. In fact, their presence may be a paleontological marker for our own species, Homo sapiens. The function of the paranasal sinuses remains largely unknown, and theories as to their role vary from that of non-functional byproducts of facial structure to that of structures playing a key role, along with the nasal cavity, in heating and humidification of inspired air. This research will investigate the relationship between the paranasal sinuses and nasal cavity in both humans and a range of non-human primates and other mammals. The research will involve three main components: 1) comparative dissections of the region using postmortem materials in the laboratory of Dr. Jeffrey Laitman at the Mount Sinai School of Medicine, including developmental and histological analyses of humans terrestrial and aquatic mammals; 2) craniometric study of external bony landmarks and measurement of internal volumes at the American Museum of Natural History, using both calipers and a three dimensional digitizer; 3) the use of imaging technologies such as computer assisted tomographs (CT-scans) and magnetic resonance imaging (MRI)-scans) which will provide the opportunity to visualize this region in a manner which was unapproachable previously. Three dimensional reconstructions will permit the calculation of volume and mucosal area of paranasal sinuses and nasal cavities as well as to examine developmental series in greater detail. This research will form the core of the doctoral dissertation of Mr. Samuel Marquez, graduate student in the Ph.D. Program in Anthropology of CUNY, whose co-thesis advisors are Professors Eric Delson (Lehman and the American Museum of Natural History) and Jeffrey Laitman (Mount Sinai). The project is an outgrowth of their previous funded research on facial architecture in Old World monkeys and apes, and on development and evolution of the upper respiratory tract in humans and apes, respectively. Mr. Marquez will be trained and mentored by them at their institutions, and his research will be directed through a three-way interaction. In addition, another CUNY graduate student and an upper-level Lehman undergraduate will be provided similar training as well as the opportunity to assist Mr. Marquez in the carrying out of his research project. Both Delson and Laitman have been responsible for the training of numerous graduate students who have gone on to productive careers in anatomical and anthropological aspects of biomedical research.

Project Start
1998-07-01
Project End
1999-08-31
Budget Start
Budget End
Support Year
14
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Herbert H. Lehman College
Department
Type
DUNS #
620128301
City
New York
State
NY
Country
United States
Zip Code
10468
Zheng, Zhi-Liang (2017) Ras and Rho GTPase regulation of Pol II transcription: A shortcut model revisited. Transcription 8:268-274
Zhang, Bo; Yang, Guohua; Chen, Yu et al. (2016) C-terminal domain (CTD) phosphatase links Rho GTPase signaling to Pol II CTD phosphorylation in Arabidopsis and yeast. Proc Natl Acad Sci U S A 113:E8197-E8206
Guerrero-Berroa, Elizabeth; Kluger, Alan; Schmeidler, James et al. (2014) Neuropsychological and neuropsychiatric prediction of global cognitive status among older Spanish-speaking Hispanics and English-speaking whites. J Geriatr Psychiatry Neurol 27:266-75
Zhang, Bo; Pasini, Rita; Dan, Hanbin et al. (2014) Aberrant gene expression in the Arabidopsis SULTR1;2 mutants suggests a possible regulatory role for this sulfate transporter in response to sulfur nutrient status. Plant J 77:185-97
Sailor, Kevin; Brooks, Patricia J (2014) Do part-whole relations produce facilitation in the picture-word interference task? Q J Exp Psychol (Hove) 67:1768-85
Gharbaran, Rajendra; Alvarado, Susana; Aisemberg, Gabriel O (2014) Regional and segmental differences in the embryonic expression of a putative leech Hox gene, Lox2, by central neurons immunoreactive to FMRFamide-like neuropeptides. Invert Neurosci 14:51-8
Gharbaran, Rajendra; Aisemberg, Gabriel O (2013) Identification of leech embryonic neurons that express a Hox gene required for the differentiation of a paired, segment-specific motor neuron. Int J Dev Neurosci 31:105-15
Gharbaran, Rajendra; Aisemberg, Gabriel O; Alvarado, Susana (2012) Segmental and regional differences in neuronal expression of the leech Hox genes Lox1 and Lox2 during embryogenesis. Cell Mol Neurobiol 32:1243-53
Yang, Hui; Figueroa, Mario; To, Satoshi et al. (2010) Benzophenones and biflavonoids from Garcinia livingstonei fruits. J Agric Food Chem 58:4749-55
Vallabhaneni, Ratnakar; Bradbury, Louis M T; Wurtzel, Eleanore T (2010) The carotenoid dioxygenase gene family in maize, sorghum, and rice. Arch Biochem Biophys 504:104-11

Showing the most recent 10 out of 67 publications