The Morehouse School of Medicine's MBRS program has the overall objective of enhancing the research opportunity and productivity of the faculty, thereby providing the foundation and primary building blocks needed to establish and sustain a research program that merits funding from mainstream sources. This basic support translates into an environment where potential minority scientists may be trained to become future scientific leaders. The need for minority research scientists is not exaggerated when one looks at the extent of morbidity and mortality data on diseases and adverse conditions that affect the nations's minority population. This renewal application includes nineteen diverse biomedical research projects designed to strengthen the institution's research capabilities and provide for faculty and students the support needed to address some of these ails.
The specific aims are to: 1) enhance research in basic and clinical biomedical science at MSM, particularly research on diseases that disproportionately affect minority populations; 2) assist MSM faculty in the development of their research capability in order to increase their competitiveness for federal and non-federal support; 3) to expose minority undergraduate and attract minority graduate students to basic and clinical biomedical research; 4) encourage minority students accepted to medical school to pursue careers in biomedical research and academic medicine. This application assembles a body of superb investigators who will fulfill the objectives of this program, thereby enhancing the overall research capabilities of the institution.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
2S06GM008248-08
Application #
2167698
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1987-09-30
Project End
1998-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Morehouse School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30310
Wilson, Nana O; Solomon, Wesley; Anderson, Leonard et al. (2013) Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria. PLoS One 8:e60898
Igietseme, Joseph U; Omosun, Yusuf; Partin, James et al. (2013) Prevention of Chlamydia-induced infertility by inhibition of local caspase activity. J Infect Dis 207:1095-104
Wilson, Nana; Driss, Adel; Solomon, Wesley et al. (2013) CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria. PLoS One 8:e81329
Kim, Teayoun; Zhelyabovska, Olga; Liu, Jian et al. (2013) Generation of an inducible, cardiomyocyte-specific transgenic mouse model with PPAR ?/? overexpression. Methods Mol Biol 952:57-65
Liu, Mingli; Amodu, Audu S; Pitts, Sidney et al. (2012) Heme mediated STAT3 activation in severe malaria. PLoS One 7:e34280
Wilson, Nana O; Ceesay, Fatou K; Hibbert, Jacqueline M et al. (2012) Pregnancy outcomes among patients with sickle cell disease at Korle-Bu Teaching Hospital, Accra, Ghana: retrospective cohort study. Am J Trop Med Hyg 86:936-42
Shelton, Martin N; Huang, Ming-Bo; Ali, Syed A et al. (2012) Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol 86:406-19
Campbell, Patrick E; Isayev, Olexandr; Ali, Syed A et al. (2012) Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling. J Mol Model 18:4603-13
Wilson, Nana O; Ceesay, Fatou K; Obed, Samuel A et al. (2011) Intermittent preventive treatment with sulfadoxine-pyrimethamine against malaria and anemia in pregnant women. Am J Trop Med Hyg 85:12-21
Lucchi, Naomi W; Jain, Vidhan; Wilson, Nana O et al. (2011) Potential serological biomarkers of cerebral malaria. Dis Markers 31:327-35

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