The overall goal of the Morehouse School of Medicine (MSM) MBRS SCORE Program is to enhance the research capability of MSM faculty by supporting biomedical research related to disease processes that disproportionately affect underserved population. The design of the program will foster the research career goals of our mid-level and/or mature research faculty and will aid our young faculty in initiating their independent research programs. This renewal application includes twenty-six diverse biomedical research projects (20 full and 6 pilots) that will strengthen the institution's research capabilities and provide for faculty the needed support to address the disproportionate degree of diseases and adverse conditions that affect the nation's minority population. The MBRS SCORE will also provide the resources and technical assistance needed to maintain an environment for developing and cultivating minority students to become outstanding scientists. The Program Goals are to: 1) enhance the research environment for MSM faculty, 2) increase the faculty scholastic productivity and 3) coordinate the faculty research activities of the SCORE with the student, faculty, and institutional development activities of the RISE. The measurable outcomes expected to result from accomplishing Goal 1 are: 1) a 20% concentration (4 out of 20) of the MBRS-sponsored seminars focused on cutting-edge technologies; 2) the selection of 4 SCORE investigators/year to present their research findings during the MBRS-sponsored seminar series; 3) two technical workshops (e.g. bioinformatics and advanced molecular biology techniques) supported and coordinated by the MBRS program; 4) an increase in the number of MBRS-sponsored seminars by 25% (from 16 to 20). The measurable outcomes expected to result from accomplishing Goal 2 are: 1) a 50% increase in the number (from 1 to 2) of manuscripts accepted for publication/project/year; 2) an increased number (15%) of extramurally funded grants; 3) a structured procedure which will provide periodic feedback and a means of monitoring the progress and/or obstacles of each investigators research. The measurable outcomes expected to result from accomplishing Goal 3 are: 1) the exposure of minority under-graduate students to research training that provides a full range of research experiences (e.g. hands-on experimentations, scientific writing, currents technologies, etc); 2) an enhancement of the institution's graduate programs; 3) a group of junior investigators that are equipped with the elements needed to begin developing a sound research program.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
2S06GM008248-16
Application #
6508481
Study Section
Special Emphasis Panel (ZGM1-MBRS-1 (01))
Program Officer
Poodry, Clifton A
Project Start
1987-09-30
Project End
2006-07-31
Budget Start
2002-09-30
Budget End
2003-07-31
Support Year
16
Fiscal Year
2002
Total Cost
$2,538,664
Indirect Cost
Name
Morehouse School of Medicine
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30310
Wilson, Nana O; Solomon, Wesley; Anderson, Leonard et al. (2013) Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria. PLoS One 8:e60898
Igietseme, Joseph U; Omosun, Yusuf; Partin, James et al. (2013) Prevention of Chlamydia-induced infertility by inhibition of local caspase activity. J Infect Dis 207:1095-104
Wilson, Nana; Driss, Adel; Solomon, Wesley et al. (2013) CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria. PLoS One 8:e81329
Kim, Teayoun; Zhelyabovska, Olga; Liu, Jian et al. (2013) Generation of an inducible, cardiomyocyte-specific transgenic mouse model with PPAR ?/? overexpression. Methods Mol Biol 952:57-65
Shelton, Martin N; Huang, Ming-Bo; Ali, Syed A et al. (2012) Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol 86:406-19
Campbell, Patrick E; Isayev, Olexandr; Ali, Syed A et al. (2012) Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling. J Mol Model 18:4603-13
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Wilson, Nana O; Ceesay, Fatou K; Hibbert, Jacqueline M et al. (2012) Pregnancy outcomes among patients with sickle cell disease at Korle-Bu Teaching Hospital, Accra, Ghana: retrospective cohort study. Am J Trop Med Hyg 86:936-42
Wilson, Nana O; Ceesay, Fatou K; Obed, Samuel A et al. (2011) Intermittent preventive treatment with sulfadoxine-pyrimethamine against malaria and anemia in pregnant women. Am J Trop Med Hyg 85:12-21
Lucchi, Naomi W; Jain, Vidhan; Wilson, Nana O et al. (2011) Potential serological biomarkers of cerebral malaria. Dis Markers 31:327-35

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