Abstract

The MBRS Program of the University of California, San Diego (UCSD), is submitting its renewal application consisting of 15 Associate Investigator Projects for a four-year period. UCSD is directing its MBRS Program focus through a joint management structure consisting of the Office of Graduate Studies and Research, vice Chancellor for Undergraduate Affairs and Thurgood Marshall College. The goal of the program is to increase the number of only those underrepresented minority students who have an expressed and committed desire to achieve the Ph.D. degree in the biomedical sciences. This goal has been achieved through the following objectives: a) Including a cadre of associate investigators (AIs) with strong extramural grant support and with a commitment to the goals of the MBRS Program. b) Linking MBRS undergraduate and graduate students early on with the above AIs who will serve as undergraduate mentors and graduate advisors. c) Providing student participants with direct assistance in preparing for the GRE, Graduate School Applications and National Fellowships. d) Establishing a follow-up database composed of UCSD-MBRS students. Support is requested for undergraduates and Ph.D. level graduate students.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM047165-07
Application #
2654969
Study Section
Minority Programs Review Committee (MPRC)
Project Start
1991-09-20
Project End
2000-01-31
Budget Start
1998-02-01
Budget End
1999-01-31
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Organized Research Units
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Mathieu-Costello, O; Morales, S; Savolainen, J et al. (2002) Fiber capillarization relative to mitochondrial volume in diaphragm of shrew. J Appl Physiol 93:346-53
Chang, N; Uribe, J M; Keely, S J et al. (2001) Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 281:G129-37
McMorris, T C; Lira, R; Gantzel, P K et al. (2000) Sesquiterpenes from the basidiomycete Omphalotus illudens. J Nat Prod 63:1557-9
Buck, M; Kim, D J; Houglum, K et al. (2000) c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 278:G321-8
Houglum, K; Buck, M; Kim, D J et al. (1998) TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region. Am J Physiol 274:G840-7
Chojkier, M; Houglum, K; Lee, K S et al. (1998) Long- and short-term D-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression. Am J Physiol 275:G1480-5
Houglum, K; Lee, K S; Chojkier, M (1997) Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133. J Clin Invest 99:1322-8
Lin, V S; Motesharei, K; Dancil, K P et al. (1997) A porous silicon-based optical interferometric biosensor. Science 278:840-3
Otonkoski, T; Cirulli, V; Beattie, M et al. (1996) A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 137:3131-9
Lee, K S; Buck, M; Houglum, K et al. (1995) Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-8

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