Abstract

The use of implantable prosthetic devices has gained acceptance over the last thirty years as a reliable treatment for people afflicted with diseased or damaged joints. The design of these implants has progressed to the point where patients are leading pain free, relatively active lives. As the life expectancy of implant recipients has increased, it has been found that the bond between the implant and the bone degrades, necessitating further corrective surgery. We propose to develop a novel organo-calcium precursor for use in depositing films of calcium phosphate hydroxyapatite on implants by chemical vapor deposition. The hydroxyapatite is a major component of bone and it has been found that its use as a coating promotes bonding between the bone and the implant, thereby fully incorporating the device into the living tissue. Chemical vapor deposition will provide a conformal, uniform coating that will maximize the benefits of using hydroxyapatite and will also provide an economical, high volume means to deposit the material.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
1S06GM054650-01
Application #
5212297
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ratna, Warren N; Bhatt, Vrushank D; Chaudhary, Kawshik et al. (2016) Estrogen-responsive genes encoding egg yolk proteins vitellogenin and apolipoprotein II in chicken are differentially regulated by selective estrogen receptor modulators. Theriogenology 85:376-83
Cohen, Carl I; Ryu, Helen H (2015) A Longitudinal Study of the Outcome and Associated Factors of Subsyndromal and Syndromal Depression in Community-Dwelling Older Adults with Schizophrenia Spectrum Disorder. Am J Geriatr Psychiatry 23:925-33
Tuck, Natalie L; Consedine, Nathan S (2015) Breast cancer screening: the role of attachment. Psychol Health Med 20:400-9
Cohen, Carl I; Iqbal, Mudassar (2014) Longitudinal study of remission among older adults with schizophrenia spectrum disorder. Am J Geriatr Psychiatry 22:450-8
Cohen, Carl I; Natarajan, Navin; Araujo, Marie et al. (2013) Prevalence of negative symptoms and associated factors in older adults with schizophrenia spectrum disorder. Am J Geriatr Psychiatry 21:100-7
Cohen, Carl I; Solanki, Dishal; Sodhi, Dimple (2013) Interpersonal conflict strategies and their impact on positive symptom remission in persons aged 55 and older with schizophrenia spectrum disorders. Int Psychogeriatr 25:47-53
Consedine, Nathan S; Fiori, Katherine L; Tuck, Natalie L et al. (2013) Attachment, activity limitation, and health symptoms in later life: the mediating roles of negative (and positive) affect. J Aging Health 25:56-79
Merz, Eva-Maria; Consedine, Nathan S (2012) Ethnic group moderates the association between attachment and well-being in later life. Cultur Divers Ethnic Minor Psychol 18:404-15
Consedine, Nathan S (2012) The demographic, system, and psychosocial origins of mammographic screening disparities: prediction of initiation versus maintenance screening among immigrant and non-immigrant women. J Immigr Minor Health 14:570-82
Consedine, Nathan S; Fiori, Katherine L; Magai, Carol (2012) Regulating emotion expression and regulating emotion experience: divergent associations with dimensions of attachment among older women. Attach Hum Dev 14:477-500

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