New developments in biomedical signaling processing have produced new tools for the understanding of biological/biomedical phenomena. Using these methods we have found a direct experimental link between speech production, the hearing derived psychoacoustic mel-scale, and the basilar membrane. Our results provide an explanation about how communication is possible, in spite of speech being produced from physiologically different sources, for example, adult vocal tract versus a child's vocal-tract. Based on these results a direct aim of the proposed research is the improvement of cochlear implants, which currently suffer serious degradation in intelligibility in the presence of noise. We also apply these new methods to balance problems and propose new time-frequency methods to understand the response of individuals to visual stimulus. It has been shown that the response produces a non- stationary signal and hence time-frequency methods are essential. Understanding balance and having markers for detection of early onset is particularly important for the aging population, which is one of the groups we will study. Also, we propose new medical imaging methods for image enhancement, texture analysis, and image registration. The proposed research aims at detecting and classifying texture, which is often an indicator of diseased tissue, and aims to developing methods that will enhance images by fusion images obtained from different sources or modalities, which is common in diagnostic medical imaging.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
1S06GM060654-01
Application #
6313789
Study Section
Minority Programs Review Committee (MPRC)
Project Start
2000-04-01
Project End
2004-03-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
$59,461
Indirect Cost
Name
Hunter College
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10065
Luine, Victoria; Gomez, Juan; Beck, Kevin et al. (2017) Sex differences in chronic stress effects on cognition in rodents. Pharmacol Biochem Behav 152:13-19
Gupta, Rupal; Huang, Wenlin; Francesconi, Lynn C et al. (2017) Effect of positional isomerism and vanadium substitution on 51V magic angle spinning NMR Spectra Of Wells-Dawson polyoxotungstates. Solid State Nucl Magn Reson 84:28-33
Luine, Victoria (2016) Estradiol: Mediator of memories, spine density and cognitive resilience to stress in female rodents. J Steroid Biochem Mol Biol 160:189-95
Luine, Victoria (2015) Recognition memory tasks in neuroendocrine research. Behav Brain Res 285:158-64
Frankfurt, Maya; Luine, Victoria (2015) The evolving role of dendritic spines and memory: Interaction(s) with estradiol. Horm Behav 74:28-36
DeCicco, Jennifer M; O'Toole, Laura J; Dennis, Tracy A (2014) The late positive potential as a neural signature for cognitive reappraisal in children. Dev Neuropsychol 39:497-515
Luine, Victoria N (2014) Estradiol and cognitive function: past, present and future. Horm Behav 66:602-18
Garcia, Miguel; Ray, Sibnath; Brown, Isaiah et al. (2014) PakD, a putative p21-activated protein kinase in Dictyostelium discoideum, regulates actin. Eukaryot Cell 13:119-26
O'Toole, Laura J; DeCicco, Jennifer M; Berthod, Samantha et al. (2013) The N170 to angry faces predicts anxiety in typically developing children over a two-year period. Dev Neuropsychol 38:352-63
Garcia, Rebecca; Nguyen, Liem; Brazill, Derrick (2013) Dictyostelium discoideum SecG interprets cAMP-mediated chemotactic signals to influence actin organization. Cytoskeleton (Hoboken) 70:269-80

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