Although a tremendous volume of research has addressed both physiological and sociocultural factors in substance abuse, surprisingly little research effort has been devoted to the role and importance of cognitive factors in this behavior. There is an important gap in the literature, especially in view of the fact that there is an established link between substance abuse and attention deficit hyperactive disorder (ADHD), a condition which results in a number of important cognitive anomalies. The proposed research will address the relationships between attention deficit disorder, related co-morbid conditions, and substance abuse behavior, with special reference to two types of cognitive processing which are likely to characterize the individual with ADHD, specifically metonymic processing and an enhanced vulnerability to the consequences of the availability heuristic in deciding whether or not to engage in substance abuse. A series of experiments is proposed which will characterize these relationships in a large non-referred adolescent population and in the general population of a culturally rich multi-ethnic area; this is especially important in that much of the available research on ADHD and substance abuse has addressed only referred populations, a source of significant potential bias. The proposed research is intended to result in a formal structural equation model of the relationships of ADHD, co-morbid conditions, cognitive processing factors, and substance abuse, from with a precise and predictive understanding of these relationships can be formed.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
1S06GM061223-01
Application #
6332137
Study Section
Minority Programs Review Committee (MPRC)
Project Start
2000-06-01
Project End
2004-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
$32,217
Indirect Cost
Name
California State University Fresno
Department
Type
DUNS #
793751087
City
Fresno
State
CA
Country
United States
Zip Code
93726
Van Laer, Koen; Buts, Lieven; Foloppe, Nicolas et al. (2012) Mycoredoxin-1 is one of the missing links in the oxidative stress defence mechanism of Mycobacteria. Mol Microbiol 86:787-804
Upton, Heather; Newton, Gerald L; Gushiken, Melissa et al. (2012) Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis. FEBS Lett 586:1004-8
Newton, Gerald L; Fahey, Robert C; Rawat, Mamta (2012) Detoxification of toxins by bacillithiol in Staphylococcus aureus. Microbiology 158:1117-26
Ta, Philong; Buchmeier, Nancy; Newton, Gerald L et al. (2011) Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants. J Bacteriol 193:1981-90
Newton, Gerald L; Leung, Stephan S; Wakabayashi, Judy I et al. (2011) The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases. Biochemistry 50:10751-60
Gaballa, Ahmed; Newton, Gerald L; Antelmann, Haike et al. (2010) Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A 107:6482-6
Johnson, Todd; Newton, Gerald L; Fahey, Robert C et al. (2009) Unusual production of glutathione in Actinobacteria. Arch Microbiol 191:89-93
Miller, Christopher C; Rawat, Mamta; Johnson, Todd et al. (2007) Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol. Antimicrob Agents Chemother 51:3364-6
Rawat, Mamta; Johnson, Chantale; Cadiz, Vanessa et al. (2007) Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. Biochem Biophys Res Commun 363:71-6
Rawat, Mamta; Av-Gay, Yossef (2007) Mycothiol-dependent proteins in actinomycetes. FEMS Microbiol Rev 31:278-92

Showing the most recent 10 out of 15 publications